Does a normal homocysteine level imply that you don't need to treat MTHFR? Find out in this video!
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EXPLORE WITH YOUR CARE TEAM
Compare the products below, including their ingredients and available forms. Your care team can help you choose one or more options for your needs.
Explore supplements Dr. Purser discusses for methylation and antioxidant support.
COMPARE YOUR OPTIONS
Dr. Purser discusses these supplements in relation to MTHFR.
MTHFR Daily and Hydroxy B12 + Folinic Acid are alternatives. Your folate, vitamin B12, and genetic results can help your clinician choose between them.
CAPSULES & LIQUID
Choose between capsule and liquid forms with your clinician.
SUPPLEMENT OPTIONS
Ask your clinician how this option fits your results and current medicines.
SUPPLEMENT OPTIONS
Ask your clinician how this option fits your results and current medicines.
Tell your care team which supplements and medicines you already take. Check the product page for current ingredients, prices, and availability.
Also in Homocysteine: follow the connections
Most people have never heard of homocysteine , yet this small molecule may hold the key to understanding inflammation, cardiovascular disease, neurological problems, and many chronic conditions. For decades, homocysteine was viewed as a toxic substance in the blood. Doctors were taught that lowering it with B-vitamins might reduce heart disease risk. But research results were inconsistent, leaving many physicians unsure whether homocysteine truly mattered. New research and clinical observations are changing that view. We introduce a new framework called the Purser Model , which explains why ho
Also in Homocysteine: follow the connections
Dr. Purser shares his clinical perspective on homocysteine, methylation, and inflammatory patterns.
Also in Homocysteine: follow the connections
High homocysteine signals a broken transsulfuration pathway, leaving you unable to detox or convert it into glutathione. This shows up in conditions like PCOS and fibromyalgia, where patients often struggle with inflammation, pain, and even infertility. Genetics play a big role—there are 17 SNPs that can lock homocysteine in place—but vitamin deficiencies can make it worse. The real breakthrough isn’t lowering homocysteine itself but calming the cytokines it triggers, like IL-8 and MCP-1. That’s why VARS Glutathione, the only patented oral form proven to work, is so powerful—it lowers those cy
Searchable captionsAlso in Homocysteine: follow the connections
High homocysteine often shows up first as widespread inflammation—pain all over, poor circulation, or even early warning signs of cardiovascular problems like stroke and heart attack. The best way to know for sure is through testing: a blood test can measure homocysteine directly, while a CMA with Redox uncovers the vitamin deficiencies driving it. For genetic causes, the DRP Genetics panel screens 15–16 of the 17 known SNPs that can cause permanently high homocysteine. If your levels are fixed by genetics, reduced glutathione and targeted B vitamins (like MTHFR Daily) are key to balancing the
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