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Gene & pathway reference · FROM DR. PURSER’S TEACHING

TCN2

TCN2 helps carry vitamin B12 in the body. A gene result alone cannot tell you your B12 status.

Based on teaching by Dan Purser, MD. How we prepare these guides

Updated Sep 23, 2026 · Educational reference

THE TEACHING CONNECTION

B12 must be carried as well as consumed

B12 must be carried as well as consumed

TCN2 appears in Dr. Purser’s homocysteine and methylation map because it concerns the transport of B12. The teaching distinction is between eating or supplementing a vitamin, transporting it, and using it in an enzyme reaction.

Putting the pieces together

TCN2 connects to how B12 is carried in the body. Your clinician may compare this result with B12 measurements, the form you already take, and your response. A TCN2 result does not by itself confirm a B12 deficiency.

Where the VARS Triad and MTHFR Daily fit

If you are exploring homocysteine or cytokines, Dr. Purser may discuss MTHFR Daily and the VARS Triad: VARS Glutathione, VARS SOD, and VARS Catalase. He gives glutathione a central place in his approach to antioxidant support.

A gene result alone cannot tell you that you need these products or that they will treat a condition. Review your current results, medicines, goals, and tolerance with your clinician before choosing a product or dose.

A question to bring to your visit

What evidence do we have about my B12 status beyond the genetic finding?

Reading your own results

Bring your original report, current results, health history, and medicines to your visit. This information can help you ask questions, but it cannot diagnose a condition or choose a supplement dose for you.

Variant lookup

These names can help you find an entry on your original genetic report. Seeing a name here does not tell you whether it affects your health or whether you need treatment.

Names you may see

Transcobalamin II