Dan Purser MD and Jackson Larkin discuss the connections they consider between sugar cravings, cellular energy, and methylation.
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Dr. Purser discusses these supplements in relation to MTHFR.
MTHFR Daily and Hydroxy B12 + Folinic Acid are alternatives. Your folate, vitamin B12, and genetic results can help your clinician choose between them.
Tell your care team which supplements and medicines you already take. Check the product page for current ingredients, prices, and availability.
Also in Methylation & B vitamins
Explore with Dr. Purser how methylation errors may be causing your fatigue. Be sure to check out the End Fibromyalgia with Natural Options Facebook page for more help and tips at facebook.com/NaturalOptionsWithLois/
Also in Your MTHFR starting point
MTHFR is one of the most studied genetic SNPs, with the two main variants being C677T and A1298C. These changes reduce the body’s ability to process folate and make energy, leaving people exhausted and deficient in key nutrients. Specialized folates, B12 forms, and glutathione can bypass the blockages, and products like MTHFR Daily were designed specifically to fill these nutrient gaps so patients can restore energy and thrive.
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Genetic SNPs are tiny changes in your DNA that can drastically affect how well your enzymes and proteins work. For example, being homozygous for MTHFR C677T leaves that enzyme functioning at only about 30% efficiency, which can drain your energy and impair folate processing. Similarly, errors in SOD genes reduce your body’s ability to neutralize free radicals. While we can’t change your genes, we can work around them by identifying these weaknesses and filling the gaps with targeted nutrition and supplementation—helping your body function closer to its full potential.
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Many vitamins and minerals go through the methylation cycle meaning a methyl group is added to a molecule to turn it into its active form. Individuals with MTHFR and other genetic methylation errors are unable to efficiently create the methylated versions of those certain vitamins and minerals. Those with MTHFR specifically cannot make enough 5-MTHF, an activated form of folate, which in turn prohibits the ability to methylate other vitamins. These errors can lead to a number of cellular deficiencies which can cause chronic fatigue, anxiety, depression (BASICALLY MAKE YOU FEEL LIKE A SLUG) and
