How to Actually Treat Homocysteine at the Root
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High homocysteine signals a broken transsulfuration pathway, leaving you unable to detox or convert it into glutathione. This shows up in conditions like PCOS and fibromyalgia, where patients often struggle with inflammation, pain, and even infertility. Genetics play a big role—there are 17 SNPs that can lock homocysteine in place—but vitamin deficiencies can make it worse. The real breakthrough isn’t lowering homocysteine itself but calming the cytokines it triggers, like IL-8 and MCP-1. That’s why VARS Glutathione, the only patented oral form proven to work, is so powerful—it lowers those cy
Searchable captionsMost glutathione supplements fail because they break down before your body can use them. VARS Glutathione is different—it’s patented, validated, and proven to raise real intracellular glutathione levels. That means it actually works to calm inflammation, lower cytokines, and protect your cells where it matters most.
Searchable captionsHigh homocysteine? It’s not the number—it’s the cytokines it triggers (like IL-8) that cause strokes, kidney failure & inflammation. We found 17 gene SNPs + 12 vitamin deficiencies that drive it—and VARS Glutathione helps shut it down.
Searchable captionsOne of the most powerful nutrients you’ve never heard of? Phosphatidylcholine. It builds the walls of your cells, protects your gut lining, supports nerve function, and even helps your body make bile. If you have a PEMT gene mutation, your body struggles to make it—and that means gut issues, nerve dysfunction, and chronic inflammation.
Searchable captionsStruggling with high blood pressure that just won’t budge—even with multiple meds? It might be due to genetic issues causing high homocysteine , which can stiffen your arteries through IL-8 and MCP-1 cytokines.
High homocysteine levels can lead to inflammation, joint and muscle pain, and even shifting pain throughout the body. It’s also linked to birth defects and chronic kidney failure, and can raise blood pressure. Six genetic SNPs (like MTR, MTRR, and CBS) and MTHFR mutations (like C677T) can prevent homocysteine from converting into glutathione, which is essential for keeping inflammation in check. Plus, 12 vitamin deficiencies may temporarily raise homocysteine levels, so addressing these deficiencies is key.
Dan Purser MD, renown for his work with MTHFR, chronic fatigue, anxiety, depression, fertility, hormone health, fibromyalgia, and SO MUCH MORE takes on the recent podcast interview of Gary Brecka from 10 Times Health System and Joe Rogan. Mr. Brecka is correct on so many points, but there is still SO MUCH MORE to dive into. The 5 genes he looks at are critical, but there are several to dozens more that need to be addressed. Once you look at genes, you must check out Intracellular Micronutrient Levels. This is THE ONLY way to get the full picture.
Dr. Purser discusses where you can find resources to learn of treatments for interstitial cystitis (chronic bladder pain). Contact us at (801) 796-7667 or info@danpursermd.com for help. Check back often for the newest updates!
Scurvy may sound like a relic of the past, but this physician is still diagnosing it today. Nutrition gaps, restrictive diets, and heavily processed foods can leave people with bleeding gums, chronic fatigue, unexplained pain, bruising, and
A post from Purser Wellness on Substack, covering cytokines and immune signaling, inflammation and antioxidants.
Discover how a common genetic variant in the PEMT gene can block your body’s ability to make phosphatidylcholine — leading to chronic pancreatitis, even if you’ve never touched alcohol.
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