THE PURSER WELLNESS ENCYCLOPEDIA

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Health BlogApr 6, 2026

MTHFR Mutations, Elevated Homocysteine & Autoimmune Inflammation: The Hidden Root Cause Most Doctors Miss

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— A Guide by the World’s Leading Homocysteine Expert For more than four decades as a practicing physician, I have watched thousands of patients cycle through conventional autoimmune treatments that address symptoms but never touch the fire underneath. Rheumatoid arthritis flares, lupus rashes, multiple sclerosis relapses, Hashimoto’s thyroiditis, fibromyalgia pain—these are not random. They share a common, often overlooked biochemical pathway: MTHFR mutations leading to elevated homocysteine that supercharges autoimmune inflammation . This is not fringe theory. It is the clinical reality I hav

SubstackMar 2, 2026

Can Glutathione Reverse Kidney Disease, Lower Blood Pressure, and Calm Cytokine Storms? What High Homocysteine May Be Doing to Your Arteries, Kidneys, and Fertility

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The Overlooked Link Between MTHFR Mutations, Hyperhomocysteinemia, PCOS, Fibromyalgia, Chronic Inflammation, and Renal Decline — and Why Precision Genetic Testing May Be the Missing Step

YouTubeMar 2, 2026

Can Glutathione Reverse Kidney Disease, Lower Blood Pressure, and Calm Cytokine Storms? What High H

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The Overlooked Link Between MTHFR Mutations, Hyperhomocysteinemia, PCOS, Fibromyalgia, Chronic Inflammation, and Renal Decline — and Why Precision Genetic Testing May Be the Missing Step https://danpursermd.substack.com/p/can-glutathione-reverse-kidney-disease?utm_source=youtube

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InstagramNov 22, 2025

A sudden spike in folate or homocysteine is rarely caused by supplements. It is most often the result of a hidden…

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A sudden spike in folate or homocysteine is rarely caused by supplements. It is most often the result of a hidden infection or minor injury triggering a cytokine surge. Identifying and treating the underlying source is the key to bringing l

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InstagramNov 2, 2025

Years ago, I watched cystic fibrosis (CF) patients receive nebulized glutathione that didn’t seem to help.

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Years ago, I watched cystic fibrosis (CF) patients receive nebulized glutathione that didn’t seem to help. Decades later, our team developed and patented the first fully functional, reduced, and stable form — VARS Glutathione. Why does thi

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InstagramOct 4, 2025

Homocysteine is a natural molecule your body makes, but when levels get too high it drives massive inflammation by…

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Homocysteine is a natural molecule your body makes, but when levels get too high it drives massive inflammation by triggering cytokine release. For some people, genetics or deficiencies cause a “fixed homocysteine rate,” meaning diet and vi

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YouTubeOct 4, 2025

What Is A Fixed Homocysteine Rate?

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Homocysteine is a natural molecule your body makes, but when levels get too high it drives massive inflammation by triggering cytokine release. For some people, genetics or deficiencies cause a “fixed homocysteine rate,” meaning diet and vitamins alone won’t lower it. In those cases, the only real way to balance it is by supporting the pathway that converts homocysteine into glutathione. That’s why reduced, stable glutathione—like VARS Glutathione—is essential, because most products are oxidized and useless by the time you take them. Info: http://www.DanPurserMD.com Supplements: https://www.PhysicianDesigned.com Books: https://www.amazon.com/-/e/B00BIKSGVQ Facebook: https://www.facebook.com/danpursermd Facebook: https://www.facebook.com/PhysicianDesigned Twitter: https://twitter.com/realdanpursermd YouTube: https://www.youtube.com/danpursermd Instagram: https://www.instagram.com/danpurser.md Pinterest: https://www.pinterest.com/danpursermd

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InstagramSep 26, 2025

Your body’s ability to detox depends on one critical pathway—turning homocysteine into glutathione. But for millions…

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Your body’s ability to detox depends on one critical pathway—turning homocysteine into glutathione. But for millions with MTHFR or other genetic SNPs, this process is broken, leaving them vulnerable to toxins, inflammation, and cytokine sto

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InstagramSep 22, 2025

Kids with cystic fibrosis often have high levels of inflammatory cytokines like IL-4, IL-5, IL-8, and IL-13, which…

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Kids with cystic fibrosis often have high levels of inflammatory cytokines like IL-4, IL-5, IL-8, and IL-13, which damage the lungs. Research shows raising glutathione can lower these cytokines, yet most products don’t work. VARS Glutathion

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