Copper, zinc & the bigger picture
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Health Blog·Website publication: Jun 11, 2026

Using the NCC Formula

From the original article
By Dan Purser MD1 min read

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This is the BEST way to look at what your Copper is really doing.

Is it getting into the cells, or building up in other places? Let’s see!

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Original sourceDan Purser MD

MAKE SENSE OF YOUR COPPER RESULTS

Non-ceruloplasmin copper calculator

Use your zinc, total copper, and ceruloplasmin blood results to estimate NCC and the copper:zinc ratio.

Zinc
Total copper
Ceruloplasmin

Copy the units exactly. Use blood results collected together when available; your clinician can help if collection dates or sample types differ.

How this estimate works

This uses the formula in Dr. Purser’s handout: NCC (µg/dL) = total copper (µg/dL) − 3 × ceruloplasmin (mg/dL). NCC percentage = NCC ÷ total copper × 100. Copper:zinc ratio = total copper ÷ zinc, using the same units.

Calculated NCC is an estimate. Test methods and how much copper is bound to ceruloplasmin can affect it. It differs from a direct lab measurement of labile or exchangeable copper. It cannot diagnose fibromyalgia or copper toxicity, or choose treatment for you. Read about the limits of calculated NCC at Mayo Clinic Laboratories ↗

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