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Gene & pathway reference · FROM DR. PURSER’S TEACHING

AHCY

The genetic-architecture chapter explains that S-adenosylmethionine (SAM) donates methyl groups and becomes S-adenosylhomocysteine (SAH).

Based on teaching by Dan Purser, MD. How we prepare these guides

Updated Sep 23, 2026 · Educational reference

THE TEACHING CONNECTION

Methyl-group use leaves another molecule behind

Methyl-group use leaves another molecule behind

The genetic-architecture chapter explains that S-adenosylmethionine (SAM) donates methyl groups and becomes S-adenosylhomocysteine (SAH). AHCY participates in the reversible reaction linking SAH with homocysteine and adenosine. This adds the SAM/SAH balance to Dr. Purser’s methylation map.

Putting the pieces together

AHCY connects to the balance of molecules involved in methylation, which is more than a question of folate intake. Rare inherited AHCY deficiency is different from most common variants. Seeing AHCY on a report does not prove that SAH is building up or that you have a rare disorder.

Where the VARS Triad and MTHFR Daily fit

If you are exploring homocysteine or cytokines, Dr. Purser may discuss MTHFR Daily and the VARS Triad: VARS Glutathione, VARS SOD, and VARS Catalase. He gives glutathione a central place in his approach to antioxidant support.

A gene result alone cannot tell you that you need these products or that they will treat a condition. Review your current results, medicines, goals, and tolerance with your clinician before choosing a product or dose.

A question to bring to your visit

Which exact variant is present, and are we discussing a common association or a clinically classified inherited disorder?

Reading your own results

Bring your original report, current results, health history, and medicines to your visit. This information can help you ask questions, but it cannot diagnose a condition or choose a supplement dose for you.

Variant lookup

These names can help you find an entry on your original genetic report. Seeing a name here does not tell you whether it affects your health or whether you need treatment.

Names you may see

Adenosylhomocysteinase