← Genes & pathways

Gene & pathway reference · FROM DR. PURSER’S TEACHING

CCL3

CCL3 encodes MIP-1 alpha, a chemokine involved in attracting and activating immune cells. It is related to CCL4, or MIP-1 beta, but the two genes and proteins are distinct.

Based on teaching by Dan Purser, MD. How we prepare these guides

Updated Sep 23, 2026 · Educational reference

THE TEACHING CONNECTION

MIP-1 alpha and the chemokine cluster

MIP-1 alpha and the chemokine cluster

CCL3 encodes MIP-1 alpha, a chemokine involved in attracting and activating immune cells. It is related to CCL4, or MIP-1 beta, but the two genes and proteins are distinct.

Putting the pieces together

Dr. Purser’s panel places CCL3 alongside the chromosome 17 chemokine cluster. The useful lesson is overlapping recruitment signals rather than a unique disease prediction from one marker. Closely related genes and nearby variants need careful naming and mapping.

Where the VARS Triad and MTHFR Daily fit

If you are exploring homocysteine or cytokines, Dr. Purser may discuss MTHFR Daily and the VARS Triad: VARS Glutathione, VARS SOD, and VARS Catalase. He gives glutathione a central place in his approach to antioxidant support.

A gene result alone cannot tell you that you need these products or that they will treat a condition. Review your current results, medicines, goals, and tolerance with your clinician before choosing a product or dose.

A question to bring to your visit

Has the exact chemokine gene been identified correctly on my report?

Variant lookup

These names can help you find an entry on your original genetic report. Seeing a name here does not tell you whether it affects your health or whether you need treatment.

Names you may see

MIP-1 alpha · MIP-1α