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Gene & pathway reference · FROM DR. PURSER’S TEACHING

CCL2

CCL2 encodes MCP-1, a chemokine that attracts monocytes toward sites of immune activity. Recruitment is a different task from the cytokines that activate those cells once they arrive.

Based on teaching by Dan Purser, MD. How we prepare these guides

Updated Sep 23, 2026 · Educational reference

THE TEACHING CONNECTION

MCP-1: recruiting monocytes

MCP-1: recruiting monocytes

CCL2 encodes MCP-1, a chemokine that attracts monocytes toward sites of immune activity. Recruitment is a different task from the cytokines that activate those cells once they arrive.

Putting the pieces together

Dr. Purser places MCP-1 in his vascular-inflammation teaching. The connection is to immune-cell traffic in vessel walls and other inflamed tissues, not a conclusion that an inherited marker proves active atherosclerosis. Compare the clinical picture with cardiovascular risk factors and any measured inflammatory findings.

Where the VARS Triad and MTHFR Daily fit

If you are exploring homocysteine or cytokines, Dr. Purser may discuss MTHFR Daily and the VARS Triad: VARS Glutathione, VARS SOD, and VARS Catalase. He gives glutathione a central place in his approach to antioxidant support.

A gene result alone cannot tell you that you need these products or that they will treat a condition. Review your current results, medicines, goals, and tolerance with your clinician before choosing a product or dose.

A question to bring to your visit

What distinguishes a genetic recruitment tendency from evidence of current vascular inflammation?

Variant lookup

These names can help you find an entry on your original genetic report. Seeing a name here does not tell you whether it affects your health or whether you need treatment.

Names you may see

MCP-1 · Monocyte chemoattractant protein 1