THE TEACHING CONNECTION
Recycling folate into usable cellular forms
Recycling folate into usable cellular forms
DHFR helps reduce folic acid and dihydrofolate to tetrahydrofolate-related forms used in cellular metabolism. This is one part of the folate system, distinct from MTHFR and folate transport into cells.
Putting the pieces together
Dr. Purser discusses DHFR when comparing folate forms. Folinic acid, folic acid and methylfolate are not interchangeable labels: they enter folate chemistry differently. The clinical conversation should include the actual supplement, dose, tolerance, B12 status and relevant medicines rather than assuming a marker means all folate processing has stopped.
A question to bring to your visit
Which folate form am I using, and what finding supports changing it?
Variant lookup
These names can help you find an entry on your original genetic report. Seeing a name here does not tell you whether it affects your health or whether you need treatment.
Names you may see
Dihydrofolate Reductase
EXPLORE WITH YOUR CARE TEAM
Supplements to explore
Compare the products below, including their ingredients and available forms. Your care team can help you choose one or more options for your needs.
COMPARE YOUR OPTIONS
Methylation support
Dr. Purser discusses these supplements in relation to DHFR.
MTHFR Daily and Hydroxy B12 + Folinic Acid are alternatives. Your folate, vitamin B12, and genetic results can help your clinician choose between them.
CAPSULES & LIQUID
Glutathione options
Dr. Purser discusses these supplements in relation to DHFR.
Some genetic results may make these options more relevant to you. Review your full genetic report with your clinician before choosing a supplement.
Tell your care team which supplements and medicines you already take. Check the product page for current ingredients, prices, and availability.
