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Gene & pathway reference · FROM DR. PURSER’S TEACHING

IL22

IL22 encodes a cytokine that acts on tissues such as epithelial barriers. It can support barrier defense and repair, while its effects depend on the tissue and inflammatory setting.

Based on teaching by Dan Purser, MD. How we prepare these guides

Updated Sep 23, 2026 · Educational reference

THE TEACHING CONNECTION

Barrier defense, repair and excess tissue growth

Barrier defense, repair and excess tissue growth

IL22 encodes a cytokine that acts on tissues such as epithelial barriers. It can support barrier defense and repair, while its effects depend on the tissue and inflammatory setting.

Putting the pieces together

Dr. Purser discusses IL-22 in mucosal protection, psoriasis, ulcerative-colitis and pregnancy-related inflammatory contexts. These different roles explain why simply describing a cytokine as good or bad is incomplete. A variant cannot establish barrier failure or predict a pregnancy complication.

Where the VARS Triad and MTHFR Daily fit

If you are exploring homocysteine or cytokines, Dr. Purser may discuss MTHFR Daily and the VARS Triad: VARS Glutathione, VARS SOD, and VARS Catalase. He gives glutathione a central place in his approach to antioxidant support.

A gene result alone cannot tell you that you need these products or that they will treat a condition. Review your current results, medicines, goals, and tolerance with your clinician before choosing a product or dose.

A question to bring to your visit

Which tissue and diagnosed condition are relevant to this barrier-repair discussion?

Variant lookup

These names can help you find an entry on your original genetic report. Seeing a name here does not tell you whether it affects your health or whether you need treatment.

Names you may see

IL-22 · Interleukin 22