THE TEACHING CONNECTION
Presenilin and inherited neurological disease
Presenilin and inherited neurological disease
PSEN1 encodes a presenilin protein that participates in gamma-secretase, a protein-processing complex. Some pathogenic variants can cause familial Alzheimer’s disease; a listed common marker is not equivalent to that diagnosis.
Putting the pieces together
Dr. Purser includes PSEN1 in his brain-health teaching and discusses antioxidant support in that broader context. A family pattern of early-onset dementia or a pathogenic laboratory classification needs genetic counseling and specialist review. A supplement should not be presented as proven prevention of familial Alzheimer’s disease from this marker.
A question to bring to your visit
Is this a clinically classified pathogenic variant, or a marker without an established disease-causing interpretation?
Variant lookup
These names can help you find an entry on your original genetic report. Seeing a name here does not tell you whether it affects your health or whether you need treatment.
Names you may see
Presenilin 1
EXPLORE WITH YOUR CARE TEAM
Supplements to explore
Compare the products below, including their ingredients and available forms. Your care team can help you choose one or more options for your needs.
CAPSULES & LIQUID
Glutathione options
Explore supplements Dr. Purser discusses for methylation and antioxidant support.
Choose between capsule and liquid forms with your clinician.
Tell your care team which supplements and medicines you already take. Check the product page for current ingredients, prices, and availability.
