THE TEACHING CONNECTION
Lipid transport and brain-health risk
Lipid transport and brain-health risk
APOE encodes a protein that carries lipids between cells. The familiar APOE e2, e3 and e4 groupings depend on the combination of rs429358 and rs7412, not on either marker read in isolation.
Putting the pieces together
Dr. Purser includes APOE in his late-onset Alzheimer’s teaching. This is a reason to discuss cardiovascular and brain health together: blood pressure, lipids, glucose, sleep and family history add information that a genotype cannot supply. APOE risk is probabilistic and does not diagnose dementia or predict a certain outcome.
A question to bring to your visit
Has my APOE type been interpreted from both markers, and which modifiable health factors matter for me?
Variant lookup
These names can help you find an entry on your original genetic report. Seeing a name here does not tell you whether it affects your health or whether you need treatment.
Names you may see
Apolipoprotein E
EXPLORE WITH YOUR CARE TEAM
Supplements to explore
Compare the products below, including their ingredients and available forms. Your care team can help you choose one or more options for your needs.
SUPPLEMENT OPTIONS
Brite Brain
Dr. Purser discusses these supplements in relation to APOE.
Some genetic results may make these options more relevant to you. Review your full genetic report with your clinician before choosing a supplement.
Tell your care team which supplements and medicines you already take. Check the product page for current ingredients, prices, and availability.
