Folate deficiency- causes some nasty symptoms, but where does it really come from? Both MTHFR and FOLR2 genes handle…

Supports DNA synthesis and one-carbon metabolism, including the pathway that processes homocysteine.

Makes an enzyme that helps produce a form of folate used in the processing of homocysteine. Common variants are different from rare variants that cause severe MTHFR deficiency.

FOLR2 encodes folate receptor beta, a folate-binding protein expressed in particular cell types, including subsets of immune cells. It is distinct from the FOLR1 receptor and the SLC19A1 reduced folate carrier.

<4.0 suggests deficiency. Recent intake or supplementation may raise serum values.