THE PURSER WELLNESS ENCYCLOPEDIA

Let’s explore “B vitamins and bone health”

A RELATED COURSEMethylation & B vitamins

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YouTubeAug 6, 2026

OVER-METHYLATION - Are Your B Vitamins Hurting You?

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Can the B vitamins you are taking to support energy and methylation eventually make you feel worse? In this video, Jackson Larkin explains what practitioners often call “overmethylation,” a possible adverse response to supplemental methyl donors such as: • 5-MTHF or methylfolate • Methylcobalamin • Trimethylglycine, also called TMG • Multiple overlapping methylation formulas Possible warning signs can include irritability, anxiety, restlessness, insomnia, brain fog, fatigue, and feeling “wired but tired.” These symptoms do not prove that you are overmethylated. They can have many possible causes. The timing of symptoms, your total supplement exposure, nutrient status, genetics, medications, and health history all need to be considered. In this video, we discuss: • Why methylation is essential • How methyl-donor supplements support the body • Why the right vitamin can become the wrong dose • Ingredients to look for on your supplement labels • Why some people may need lower doses or non-methylated forms • How genetics and intracellular nutrient testing can guide a more personalized plan At Purser Wellness, we believe in a Start Low, Go Slow approach. The goal is not to eliminate methylation. The goal is to provide the right form and amount of support for each individual. Learn more or schedule with Purser Wellness: https://danpursermd.com Educational content only. Do not discontinue prescribed or medically necessary supplements without consulting your qualified healthcare professional. #Overmethylation #MTHFR #Methylation #B12 #Methylfolate #VitaminB12 #TMG #BrainFog #FunctionalMedicine #PurserWellness Follow Dr. Purser! Info: http://www.DanPurserMD.com Supplements: https://www.PhysicianDesigned.com Books: https://www.amazon.com/-/e/B00BIKSGVQ Facebook: https://www.facebook.com/danpursermd Facebook: https://www.facebook.com/PhysicianDesigned Twitter: https://twitter.com/realdanpursermd YouTube: https://www.youtube.com/danpursermd Instagram: https://www.instagram.com/danpurser.md Pinterest: https://www.pinterest.com/danpursermd

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InstagramNov 10, 2025

Can’t absorb iron no matter what you try? 😣 It might not be the iron — it’s your B vitamins.

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Can’t absorb iron no matter what you try? 😣 It might not be the iron — it’s your B vitamins. Fix the deficiency → fix the absorption.

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InstagramSep 2, 2025

If you feel exhausted, irritable, or worse after taking methylated B vitamins, you may be overmethylating. Too many…

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If you feel exhausted, irritable, or worse after taking methylated B vitamins, you may be overmethylating. Too many methyl groups can act like a “toxic overload,” leaving you sleepy or edgy. The fix is simple: stop high-dose methyl B’s and

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InstagramOct 16, 2023

ATP and MTHFR are closely correlated. If you cannot process folate and other B vitamins, you’re going to be tired…

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ATP and MTHFR are closely correlated. If you cannot process folate and other B vitamins, you’re going to be tired due to inefficient ATP production. This causes chronic fatigue and other symptoms. So make sure to take your MTHFR Renew and M

FacebookOct 15, 2022

Did you know that B vitamins are essential for brain health? This important class of nutrients helps with nerve…

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Did you know that B vitamins are essential for brain health? This important class of nutrients helps with nerve function, maintaining healthy skin and hair, supporting the immune system, and keeping your mood steady. But because they're wat

Health BlogMay 12, 2021

Why do I need methylated B Vitamins?

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Many vitamins and minerals go through the methylation cycle meaning a methyl group is added to a molecule to turn it into its active form. Individuals with MTHFR and other genetic methylation errors are unable to efficiently create the methylated versions of those certain vitamins and minerals. Those with MTHFR specifically cannot make enough 5-MTHF, an activated form of folate, which in turn prohibits the ability to methylate other vitamins. These errors can lead to a number of cellular deficiencies which can cause chronic fatigue, anxiety, depression (BASICALLY MAKE YOU FEEL LIKE A SLUG) and

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