THE PURSER WELLNESS ENCYCLOPEDIA

Let’s explore “Inclusion body myositis: inflammation and cellular stress”

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FacebookSep 28, 2026

When inflammation becomes persistent, simply ignoring it or chasing symptoms may leave an important question unanswered.

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When inflammation becomes persistent, simply ignoring it or chasing symptoms may leave an important question unanswered. Stop accepting that feeling bad is simply your new normal. Stop guessing. Start investigating. Start understanding.

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Gene referenceSep 23, 2026

HMGB1

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…P, participating in inflammatory signaling. Also called: A cellular protein that can act as a danger signal HMGB1 normally has functions inside the cell nucleus. When released outside cells in particular settings, it can act as a damage-as…

Gene referenceSep 17, 2026

HLA-DR region

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…ay see HLA-DR region discussed alongside Immune regulation, Inflammation, Superoxide removal, Oxidative stress, Connective tissue. These are topics to explore, not a diagnosis or a measurement of how the pathway works in your body. Understa…

YouTubeJul 19, 2026

MTHFR & The Never-Ending Sugar Crash Cycle: Why You’re Always Tired & Craving Sweets

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MTHFR & The Never-Ending Sugar Crash Cycle: Why You’re Always Tired & Craving Sweets If you have an MTHFR variant (C677T or A1298C), you may constantly battle fatigue, sugar cravings, and energy crashes — even when you’re “doing everything right.” In this video, we break down exactly why this happens: How MTHFR/methylation issues impair ATP (energy) production at the cellular level Why your body desperately reaches for quick glucose The vicious cycle of blood sugar spikes → insulin crashes → more cravings & fat storage The downstream effects on antioxidants, DNA repair, and overall energy How to finally break the cycle: Targeted supplementation that fills methylation “holes” (what we learned from 15–20k intracellular tests) Why our MTHFR Daily multivitamin was specifically formulated for this The power of CMA intracellular testing Intermittent fasting (12–16 hrs) Fasted cardio (even just a brisk walk) High-protein, real-food diet with minimal processed sugars If you’re tired of the sugar rollercoaster and want stable energy, this is for you. Links: Read the full Substack article → https://danpursermd.substack.com/p/the-mthfrsugar-craving-cycle Get your CMA intracellular testing & genetics done → Call our office or visit danpursermd.com Shop MTHFR Daily → https://physiciandesigned.com/products/mthfr-daily Have an MTHFR variant? Drop your genotype (heterozygous/homozygous) in the comments — I’m always curious! #MTHFR #SugarCravings #Methylation #ChronicFatigue #Energy #PurserWellness #FunctionalMedicine #IntermittentFasting Follow Dr. Purser! Info: http://www.DanPurserMD.com Supplements: https://www.PhysicianDesigned.com Books: https://www.amazon.com/-/e/B00BIKSGVQ Facebook: https://www.facebook.com/danpursermd Facebook: https://www.facebook.com/PhysicianDesigned Twitter: https://twitter.com/realdanpursermd YouTube: https://www.youtube.com/danpursermd Instagram: https://www.instagram.com/danpurser.md Pinterest: https://www.pinterest.com/danpursermd

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FacebookJun 15, 2026

What if one overlooked lab marker is telling you more about your health than you realize?

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…al pathways involving methylation, nutrient metabolism, and cellular g as efficiently as they should. The problem? Many people spend years chasing symptoms while never investigating why those symptoms exist in the first place. Fatigue. B…

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FacebookJun 8, 2026

What if your fatigue, inflammation, digestive issues, or chronic discomfort aren't random—and what if the answers…

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What if your fatigue, inflammation, digestive issues, or chronic discomfort aren't random—and what if the answers have been available all along? Purser Wellness Coach Jackson Larkin explains why CMA testing is challenging conventional appr

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