Let’s explore “MTHFR, homocysteine, and immune signals”

Genetics and Homocysteine: What You Should Know Homocysteine levels can be stubbornly high if you have any of seven genetic SNPs (like MTHFR, CBS, or FOLH1). When these genes are homozygous, they disrupt the transulfuration pathway, leadin

High Homocysteine Levels and Inflammation: What You Need to Know High homocysteine levels are a common issue, often linked to genetics. There are seven gene variants (like MTHFR, CBS, and others) that can make it tough to bring those level

PURSER WELLNESSGENOVA™ Neopterin Biopterin Urine Profile for MTHFRFrom the reading room

This test result is bad and could indicate an infection, especially viral. This is a great test for those with A1298C and especially who are Homozygous A1298C. Neopterin is bad while biopterin is good. If neopterin is repeatedly high, the BH4 is low. Neopterin is a sensitive marker of cellular mediated immunity. Reduced levels reflect cellular immunity weakening. Increased neopterin occur with infectious, inflammatory, immune system dysfunction or neoplastic disease evolution. Excessive neopterin negatively impacts the Nitric Oxide pathway in the body (e.g. excessive peroxynitrite formation an

PURSER WELLNESSGlutathione: The Treatment You Need #substack #shortsA conversation with Dr. Purser

This is a clip from https://danpursermd.substack.com/p/high-homocysteine-mthfr-mutations?utm_source=youtube_shorts See the full video: https://www.youtube.com/watch?v=HuQbQ1IqNIM #shorts #substack

PURSER WELLNESSHigh homocysteine isn’t just a lab number—it’s a warning sign.A conversation with Dr. Purser

…f you have genetic errors in your methylation cycle such as MTHFR, MTR, MTRR, GGH and many others, this directly affects your homoyine production in the transforation pathway. So MTHFR could be one of the top causes of strokes and kidney fa…

Glutathione and MTHFR are connected, but what does that mean for you? If you have a methylation error in your genes, you probably aren't making glutathione sufficiently in your cells, leaving you constantly dragging. Boost your glutathion

…ne is part of the body’s antioxidant network. Monocytes are immune cells that can release cytokines when they receive stress or danger signals. Follow the pathway Dr. Purser discusses reactive oxygen species, NF-κB, NLRP3, and the cytokine…

… stress, and the kidney’s filtering structures. He connects immune signaling with reactive oxygen species and antioxidant defenses while keeping these mechanisms distinct from a confirmed cause of kidney failure. Bring these questions to y…

Learn about the interferon and IL-15 pathways described in this teaching.

If you’ve been struggling with severe chronic fatigue, unexplained anxiety, or cardiovascular red flags, your genes might be trying to tell you something. Millions of patients walk out of traditional clinics with normal blood tests, only to be told their crippling symptoms are "all in their head." If you carry the C677T variant, you aren't crazy—you are dealing with a breakdown in cellular biochemistry. The Problem With Synthetic Folic Acid The standard advice from standard doctors is to take synthetic folic acid. For someone with the C677T genetic mutation, this is disastrous. Your enzyme pat

PURSER WELLNESSThe Master MTHFR Protocol Dr. Purser DesignedFrom the reading room

Your local doctor will likely tell you that MTHFR testing and taking an MTHFR Daily supplement is a waste of money. They might even claim it isn't a real medical issue. After 15 years of hearing this pap, I can tell you they are flat-out wrong . Every day that I run into abject medical ignorance—where medicine arrogantly refuses to bend to the hard truth of proven science—I remember Ignaz Semmelweis. Semmelweis died a broken pauper in an asylum, his life destroyed by the conventional doctors of his generation who refused to accept handwashing. Their dismissive attitude today stems not from mal

…red or stressed cells, it can act as a danger signal to the immune system. Follow the pathway Dr. Purser explains the connection between HMGB1, receptors such as RAGE and TLR4, NF-κB signaling, and ongoing tissue inflammation. He also disc…