COMPARE YOUR OPTIONS
Methylation support
MTHFR Daily and Hydroxy B12 + Folinic Acid are alternatives. Your folate, vitamin B12, and genetic results can help your clinician choose between them.
INTERACTIVE PATHWAY · TWO CONNECTED STORIES
MTHFR, the citric acid cycle & ATP
Choose a stop to see what it does. Follow the folate side, then the energy side. The connection is ATP used to make SAM.
THE BIG PICTURE · TAP ANY STOP
Two stories. One energy connection.
Choose a stop to update the lesson below, or follow the story in order.
02 / MITOCHONDRIAL ENERGY
The cycle makes energy carriers. MTHFR works on folate in a separate route. ATP connects the stories.
YOU ARE HERE · 1 / 14Prepare folate
STEP 1 / 14Pick a stop, or let the story guide you.
12 seconds per step · no autoplay
Step 1 of 14: Prepare folate.
STORY 1 · FOLATE & METHYLATION
MTHFR prepares folate
MTHFR helps make 5-MTHF, a form of folate.
The MTHFR enzyme helps change 5,10-methylene-THF into 5-MTHF. It uses a vitamin B2-derived helper called FAD. Think of this as preparing a methyl group for the next step. It is not a step in the citric acid cycle.
FOLATE & METHYLATION
Folate
5-MTHF
MTHFR · vitamin B2 helps
Simplified teaching view · movement shows the idea, not your own pathway speed.
Products in the methylation conversation
EXPLORE WITH YOUR CARE TEAM
Supplements to explore
Compare the products below, including their ingredients and available forms. Your care team can help you choose one or more options for your needs.
Compare supplement options related to Vitamin B9.
SUPPLEMENT OPTIONS
Vitamin B9 supplement options
Different products offer different forms and amounts. Compare the labels with your clinician to find what fits your needs.
See more supplement options
SUPPLEMENT OPTIONS
Super Liquid Folate
Different products offer different forms and amounts. Compare the labels with your clinician to find what fits your needs.
Tell your care team which supplements and medicines you already take. Check the product page for current ingredients, prices, and availability.
Explore “what if” connections
Follow the whole story The citric acid cycle loads energy carriers. The respiratory chain helps make ATP. A separate methylation step spends some ATP to make SAM.
Read every reaction Folate, all eight cycle stops & ATP
STORY 1 · FOLATE & METHYLATION
Prepare a methyl group. Use ATP.
MTHFR and MTR act in folate and homocysteine recycling. These are not steps of the citric acid cycle.
- What happens here?
The MTHFR enzyme helps change 5,10-methylene-THF into 5-MTHF. It uses a vitamin B2-derived helper called FAD. Think of this as preparing a methyl group for the next step. It is not a step in the citric acid cycle.
The bridge between stories Energy metabolism supplies ATP. The cell spends ATP to make SAM from methionine. Mitochondria also use methyl groups for some upkeep jobs. Those connections do not mean MTHFR directly runs the citric acid cycle.
STORY 2 · MITOCHONDRIAL ENERGY
From fuel to usable ATP
Tap each stage. Open a stop in the cycle to see what is passed along.
THE CITRIC ACID CYCLE
One turn, eight stops
Acetyl-CoA enters. NADH, FADH₂ and a small amount of GTP or ATP carry energy out. The cycle returns to its starting helper.
Oxaloacetate is ready for another acetyl-CoA. Energy carriers travel onward.
