Let’s explore “A1298C”

Makes an enzyme that helps produce a form of folate used in the processing of homocysteine. Common variants are different from rare variants that cause severe MTHFR deficiency.

MTHFR is one of the most studied genetic SNPs, with the two main variants being C677T and A1298C. These changes reduce the body’s ability to process folate and make energy, leaving people exhausted and deficient in key nutrients. Specialize

If you have MTHFR gene mutations like C677T or A1298C, you’re likely low in more than just B12 and folate. 🧬 We consistently see deficiencies in B6 (pyridoxine), glutamine, glutathione, and sometimes methionine—all key players in energy, de

PURSER WELLNESSMTHFR & The Never-Ending Sugar Crash Cycle: Why You’re Always Tired & Craving SweetsA conversation with Dr. Purser

MTHFR & The Never-Ending Sugar Crash Cycle: Why You’re Always Tired & Craving Sweets If you have an MTHFR variant (C677T or A1298C), you may constantly battle fatigue, sugar cravings, and energy crashes — even when you’re “doing everything right.” In this video, we break down exactly why this happens: How MTHFR/methylation issues impair ATP (energy) production at the cellular level Why your body desperately reaches for quick glucose The vicious cycle of blood sugar spikes → insulin crashes → more cravings & fat storage The downstream effects on antioxidants, DNA repair, and overall energy How to finally break the cycle: Targeted supplementation that fills methylation “holes” (what we learned from 15–20k intracellular tests) Why our MTHFR Daily multivitamin was specifically formulated for this The power of CMA intracellular testing Intermittent fasting (12–16 hrs) Fasted cardio (even just a brisk walk) High-protein, real-food diet with minimal processed sugars If you’re tired of the sugar rollercoaster and want stable energy, this is for you. Links: Read the full Substack article → https://danpursermd.substack.com/p/the-mthfrsugar-craving-cycle Get your CMA intracellular testing & genetics done → Call our office or visit danpursermd.com Shop MTHFR Daily → https://physiciandesigned.com/products/mthfr-daily Have an MTHFR variant? Drop your genotype (heterozygous/homozygous) in the comments — I’m always curious! #MTHFR #SugarCravings #Methylation #ChronicFatigue #Energy #PurserWellness #FunctionalMedicine #IntermittentFasting Follow Dr. Purser! Info: http://www.DanPurserMD.com Supplements: https://www.PhysicianDesigned.com Books: https://www.amazon.com/-/e/B00BIKSGVQ Facebook: https://www.facebook.com/danpursermd Facebook: https://www.facebook.com/PhysicianDesigned Twitter: https://twitter.com/realdanpursermd YouTube: https://www.youtube.com/danpursermd Instagram: https://www.instagram.com/danpurser.md Pinterest: https://www.pinterest.com/danpursermd

PURSER WELLNESSWhat is MTHFR? What can YOU do about it?A conversation with Dr. Purser

MTHFR is one of the most studied genetic SNPs, with the two main variants being C677T and A1298C. These changes reduce the body’s ability to process folate and make energy, leaving people exhausted and deficient in key nutrients. Specialized folates, B12 forms, and glutathione can bypass the blockages, and products like MTHFR Daily were designed specifically to fill these nutrient gaps so patients can restore energy and thrive.

PURSER WELLNESSWhat is MTHFR?A conversation with Dr. Purser

Dr. Purser explains the diagnosis and treatment of MTHFR (methylenteterahydrofolate reductase enzyme deficiency disease). Learn the genetic component of this illness (such as C677T or A1298C) and how it affects the body's inability of methylation to convert carbohydrates into ATP (Adenosine Triphosphate). Discover how the complex enzyme pathways of the Krebs cycle and citric acid cycle convert carbohydrate molecules into ATP molecules in the mitochondria. Explore the relationship of MTHFR to vitamin and hormone deficiencies while understanding how vitamin supplements can replace key missing (u

Ever heard of MTHFR? No, it’s not a swear word—it’s a common genetic mutation that affects your body’s ability to methylate folate and produce energy from carbs. If you have the C677T or A1298C SNPs, it can lead to fatigue, brain fog, high

🚨 Can MTHFR Gene Mutations Be Dangerous? Yes. Here’s Why. 🚨 Did you know that MTHFR gene mutations can seriously impact your health? If you’re homozygous (double mutation) for multiple MTHFR SNPs—like C677T, A1298C, CBS, MTR, MTRR, and othe

Genetic variations in the MTHFR gene can affect the activity or function of the enzyme. The most well-known genetic variants are known as MTHFR C677T and MTHFR A1298C. These variations can lead to reduced enzyme activity, impacting the body

PURSER WELLNESSNew Products Coming!From the reading room

Just Some HUGE ANNOUNCEMENTS! Four NEW or super IMPROVED PRODUCTS! Our incredible improved all natural VARS MINT BURST LIPOSOMAL GLUTATHIONE — works great and tastes AMAZING! Available this week... Our new MTHFR SUPPORT PLUS is almost (nothing’s perfect— right?) for A1298C MTHFR or Compound Heterozygous MTHFR. This contains FOLINIC ACID and not the Quatrafolate that the C677T errors need. Great stuff. Try the PLUS with the MTHFR SUPPORT. MTHFR SUPPORT is available now from us with our Physician Designed label (me). Try it if you have MTHFR — BEST BASE product out there for MTHFR especially the

PURSER WELLNESSGENOVA™ Neopterin Biopterin Urine Profile for MTHFRFrom the reading room

This test result is bad and could indicate an infection, especially viral. This is a great test for those with A1298C and especially who are Homozygous A1298C. Neopterin is bad while biopterin is good. If neopterin is repeatedly high, the BH4 is low. Neopterin is a sensitive marker of cellular mediated immunity. Reduced levels reflect cellular immunity weakening. Increased neopterin occur with infectious, inflammatory, immune system dysfunction or neoplastic disease evolution. Excessive neopterin negatively impacts the Nitric Oxide pathway in the body (e.g. excessive peroxynitrite formation an

PURSER WELLNESSMTHFR and the Never-Ending Sugar Crash Cycle: Why You’re Tired, Craving Sugar, and Chasing Energy AA conversation with Dr. Purser

…e's two variants that we like to look at. The C677T and the A1298C. If you've gotten your genetic testing done, hey, let us know which one do you have. Are you hetererozygous, homozygous? I'm always super curious to know about that. So, [mu…