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Gene & pathway reference · FROM DR. PURSER’S TEACHING

COMT

Makes an enzyme that helps break down catechol compounds, including some neurotransmitters. A common variant does not by itself explain mood, attention or stress tolerance.

Based on teaching by Dan Purser, MD. How we prepare these guides

Updated Sep 23, 2026 · Educational reference

THE TEACHING CONNECTION

Catecholamines and sensitivity

Catecholamines and sensitivity

COMT helps process some chemical messengers, including dopamine and other catecholamines. Sleep, stress and how you feel after a supplement may add context; the gene alone cannot predict your behavior or mood.

Putting the pieces together

When you review a COMT result, your clinician may also look at B vitamins, magnesium, inositol, amino acids, fatty acids, and antioxidant findings. The gene result does not measure brain chemicals or replace mental health care.

Where the VARS Triad and MTHFR Daily fit

If you are exploring homocysteine or cytokines, Dr. Purser may discuss MTHFR Daily and the VARS Triad: VARS Glutathione, VARS SOD, and VARS Catalase. He gives glutathione a central place in his approach to antioxidant support.

A gene result alone cannot tell you that you need these products or that they will treat a condition. Review your current results, medicines, goals, and tolerance with your clinician before choosing a product or dose.

A question to bring to your visit

What changed after each product, caffeine change or medication change, and which current findings support the proposed explanation?

Reading your own results

Bring your original report, current results, health history, and medicines to your visit. This information can help you ask questions, but it cannot diagnose a condition or choose a supplement dose for you.

Variant lookup

These names can help you find an entry on your original genetic report. Seeing a name here does not tell you whether it affects your health or whether you need treatment.

rs165722rs165774rs4633rs4646312rs4680rs4818rs6269

Names you may see

Catechol-O-Methyltransferase

Now hear the conversation.

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PURSER WELLNESSIf you have a COMT mutation, your body may not break down estrogen or absorb B12 properly. 😵‍💫 The fix? Add DIM…A conversation with Dr. Purser
InstagramJun 30, 2025

If you have a COMT mutation, your body may not break down estrogen or absorb B12 properly. 😵‍💫 The fix? Add DIM…

If you have a COMT mutation, your body may not break down estrogen or absorb B12 properly. 😵‍💫 The fix? Add DIM (like DIM Avail) for estrogen balance and use adenosyl + hydroxy B12 for better absorption. Start with drops or go straight to c

Hormones