THE PURSER WELLNESS ENCYCLOPEDIA

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Gene referenceSep 23, 2026

GGH

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GGH encodes gamma-glutamyl hydrolase, which removes glutamate residues from folate compounds. This affects folate handling and helps explain why folate metabolism includes retention and processing as well as intake. Also called: Gamma-Gluta…

Gene referenceSep 23, 2026

GPX1

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GPX1 helps cells use glutathione to handle peroxides. Also called: Glutathione Peroxidase 1 Glutathione has enzyme partners Dr. Purser teaches the glutathione peroxidase family alongside selenium and antioxidant support. GPX1 helps illustra…

Gene referenceSep 23, 2026

GPX3

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GPX3 helps use glutathione in peroxide defense outside cells. Also called: Glutathione Peroxidase 3 Glutathione has enzyme partners Dr. Purser teaches the glutathione peroxidase family alongside selenium and antioxidant support. GPX3 helps …

Gene referenceSep 23, 2026

GPX4

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GPX4 helps protect cell membranes from certain peroxides. Also called: Glutathione Peroxidase 4 Glutathione has enzyme partners Dr. Purser teaches the glutathione peroxidase family alongside selenium and antioxidant support. GPX4 helps illu…

Gene referenceSep 23, 2026

GSR

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GSR encodes glutathione reductase. It uses reducing power from NADPH to help convert oxidized glutathione back to reduced glutathione, allowing this antioxidant system to be reused. Also called: Glutathione Reductase Recycling used glutathi…

Gene referenceSep 23, 2026

HDC

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HDC is the gene name for Histidine Decarboxylase. Learn what a specific result could mean and what to ask about it. Also called: Histidine Decarboxylase Histamine production is one part of the circuit HDC is involved in the enzyme step conv…

Gene referenceSep 23, 2026

HRH1

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HRH1 is the gene name for Histamine Receptor H1. Learn what a specific result could mean and what to ask about it. Also called: Histamine Receptor H1 Receiving the histamine signal The Purser genetics reference places HRH1 in the histamine-…

Gene referenceSep 23, 2026

MTHFD1

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MTHFD1 helps move folate between forms used for different jobs in the body. Also called: Methylenetetrahydrofolate Dehydrogenase 1 Folate has several working forms Dr. Purser includes MTHFD1 among genes involved in folate interconversion. T…

Gene referenceSep 23, 2026

MTHFD1L

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The homocysteine chapters include MTHFD1L in the wider folate-related genetic map. Also called: Methylenetetrahydrofolate Dehydrogenase 1-Like A mitochondrial contribution to one-carbon metabolism The homocysteine chapters include MTHFD1L i…

Gene referenceSep 23, 2026

MTHFR

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Makes an enzyme that helps produce a form of folate used in the processing of homocysteine. Common variants are different from rare variants that cause severe MTHFR deficiency. Also called: Methylenetetrahydrofolate Reductase, C677T, A1298C…

Gene referenceSep 23, 2026

MTRR

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Helps maintain the activity of methionine synthase, connecting B12-related chemistry with homocysteine metabolism. Also called: Methionine Synthase Reductase Keeping the remethylation system working Dr. Purser teaches MTRR alongside MTR bec…

Gene referenceSep 23, 2026

NAT2

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NAT2 encodes N-acetyltransferase 2, which helps process certain drugs and other compounds. Combinations of variants can influence acetylation status; one SNP usually does not tell the entire story. Also called: N-Acetyltransferase 2 Acetyla…

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