Let’s explore “Gout, urate crystals, and cytokines”

…eaching connects IL-10 with macrophages, T cells, and other cytokines instead of labeling every cytokine as simply good or bad. Bring these questions to your visit Ask which result is being discussed: a genetic variant, a measured protein …

…nection IL12B encodes the p40 protein subunit shared by two cytokines: IL-12 and IL-23. IL-12 combines p40 with p35; IL-23 combines p40 with p19. Follow the pathway Dr. Purser explains why the shared p40 subunit connects the Th1 and Th17 i…

…athway helps support Th17 immune cells and their downstream cytokines, including IL-17. Follow the pathway Dr. Purser connects IL-23 receptor signaling with inflammatory bowel disease, psoriasis, and inflammatory joint pathways. Targeting …

…connects TLR4 activation with NF-κB signaling, inflammatory cytokines, and the relationship between gut-barrier function and systemic immune activity. A genetic entry, soluble CD14 result, and evidence of infection describe different aspect…

PURSER WELLNESSMTHFR Mutations, Elevated Homocysteine & Autoimmune Inflammation: The Hidden Root Cause Most Doctors Miss From the reading room

…homocysteine, and a body-wide amplification of inflammatory cytokines. Homocysteine is not merely a cardiovascular marker. It is a potent “cytokine amplifier.” When levels climb above 10–12 µmol/L (my functional optimum is <7–8 µmol/L), hom…

PURSER WELLNESSHow To Know If You Have High Homocysteine?A conversation with Dr. Purser

…eted B vitamins (like MTHFR Daily) are key to balancing the cytokines and deficiencies that come with it.

…r — it’s a toxic byproduct that drives inflammation through cytokines like MCP-1 and IL-8, damaging blood vessels and disrupting hormones. Dr. Purser’s research found up to 17 genetic SNPs that can keep homocysteine high — and whether you h…

…arch shows that restoring glutathione levels can calm these cytokines, reduce inflammation, and possibly change how we approach CF and other chronic inflammatory conditions. Science is catching up — and hope is being restored.

…kthrough isn’t lowering homocysteine itself but calming the cytokines it triggers, like IL-8 and MCP-1. That’s why VARS Glutathione, the only patented oral form proven to work, is so powerful—it lowers those cytokines back to normal and hel…

…eted B vitamins (like MTHFR Daily) are key to balancing the cytokines and deficiencies that come with it.

…ough: it’s reduced, functional, and proven to lower harmful cytokines like IL-8 and MCP-1, giving your body the detox power it needs. After 15 years of research and real patient results, it’s the only oral glutathione that actually works wh…

…s. That means it actually works to calm inflammation, lower cytokines, and protect your cells where it matters most.