Let’s explore “BRCA1, BRCA2, and common variants”

…g every elevated inflammatory marker as the same problem. A common variant does not establish fibrosis. A question to bring to your visit Is there objective evidence of scarring in a specific organ, and what is the underlying cause? Variant…

…y explanation, not a way to infer ongoing cell death from a common SNP. The affected tissue and actual clinical findings determine the significance. A question to bring to your visit Is there objective evidence of tissue injury, and how is …

…a product or dose. Reading the map alongside your results A common SNP is a change at one spot in DNA. Finding one does not prove an enzyme is blocked, missing or working too fast. This map cannot measure your pathway or choose a dose. Use…

PURSER WELLNESSThe Master MTHFR Protocol Dr. Purser DesignedFrom the reading room

… be lethal if left unmanaged. Downstream Effects: Unmanaged variants lead to severe hyperhomocysteinemia, a major driver of heart attacks, strokes, hypertension, and kidney failure. If you want the deep dive on this science, read my textboo…

… an independent mental-health or neurological evaluation. A common DAOA variant does not diagnose schizophrenia, bipolar disorder, or another condition.

… rs1799945, is different from C282Y and from many other HFE variants. Follow the pathway Dr. Purser distinguishes a genetic susceptibility from measured iron overload. He discusses ferritin, transferrin saturation, liver health, and the gr…

…ase plasminogen activators. The 4G/5G promoter variation is commonly identified as rs1799889. Follow the pathway Dr. Purser discusses fibrinolysis, the process of dissolving clots, alongside homocysteine and blood-vessel inflammation. Thes…

…enetics. MTHFR is one major piece of that bigger picture. Variants such as C677T and A1298C can influence folate metabolism and methylation. Stop blaming yourself. Start understanding the biology. Support your nutrition. Support met…

…on interferon-gamma production. The same gene can have many variants with different meanings. Follow the pathway Dr. Purser follows IFN-γ signaling into T-cell and macrophage activity and the relationship between inflammation and oxidative…

…ween IL-1 alpha, IL-1 beta, and their natural antagonist. A common variant may appear in research without proving that the protective response is impaired in an individual. Bring these questions to your visit Ask which result is being disc…

…eople with chronic kidney disease, elevated homocysteine is common and has been studied in connection with cardiovascular risk and overall health. But here is where the conversation gets important. High homocysteine does not automatically…

…or XI deficiency can cause a bleeding disorder, while other variants are studied in relation to higher clotting activity. Follow the pathway Dr. Purser discusses rs2289252, factor XI activity, and the distinction between thrombosis researc…