… receive histamine signals.
Putting the pieces together
The reference discusses dietary patterns and clinician-selected antihistamine approaches in this section. These are different mechanisms, not a recommendation to combine treatments fro…
… an HLA-DQ protein that presents antigen fragments to CD4 T cells. HLA-DQ function depends on pairing with an HLA-DQB chain, so an isolated marker is not a complete HLA type.
Also called: HLADQA1, Human Leukocyte Antigen DQA1
Antigen presen…
…eptor H1
Receiving the histamine signal
The Purser genetics reference places HRH1 in the histamine-response part of the MCAS discussion. H1 receptors help mediate histamine effects; they are not the enzymes that make histamine or break it d…
…stamine also connects to stomach acid
Dr. Purser’s genetics reference connects HRH2 with histamine signaling and gastric acid secretion. H2 is a receptor, so this teaching concerns response to a signal rather than histamine production by HD…
…ing and gut immune activation. The receptor gene and a measured cytokine level are different kinds of information; a receptor variant does not tell you how much IL-23 is circulating.
More from the teaching: Putting the pieces together
Immun…
… break down some chemical messengers. A gene result cannot predict a mood or behavior.
Also called: MAO-A, Monoamine Oxidase A
Neurotransmitter breakdown in context
Dr. Purser places MAOA in the neurotransmitter-breakdown part of his brain-…
… an enzyme involved in breaking down components of the extracellular matrix. Controlled remodeling is part of repair, while excess activity can accompany inflammatory tissue damage.
Also called: Matrix Metallopeptidase 3
Remodeling the tiss…
…oose a supplement dose for you.
Variant IDs in the teaching reference: rs1076991, rs2236225
Where the VARS Triad and MTHFR Daily fit
If you are exploring homocysteine or cytokines, Dr. Purser may discuss MTHFR Daily and the VARS Triad: VARS…
…ing the pieces together
Follow the connection to folate availability and the cellular processes that use one-carbon units. The pathway provides context, but it cannot tell you from the gene name alone whether homocysteine is elevated or how…
…re MTHFR deficiency.
Also called: Methylenetetrahydrofolate Reductase, C677T, A1298C, folate, homocysteine
Follow the pathway beyond MTHFR
Dr. Purser teaches MTHFR within a larger folate and homocysteine pathway. MTHFR contributes to produc…
… status, folate status and current homocysteine been considered together?
Reading your own results
Bring your original report, current results, health history, and medicines to your visit. This information can help you ask questions, but it…
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