THE PURSER WELLNESS ENCYCLOPEDIA
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What’s searchable?IL18 encodes interleukin-18, a cytokine that can promote interferon-gamma responses in the appropriate immune context. Its receptor includes components encoded by IL18R1 and IL18RAP. Also called: An inflammatory signal that connects to int…
IL18R1 encodes a component of the receptor for IL-18. It works with an accessory component, IL18RAP, to support IL-18 signaling. Also called: The binding side of the IL-18 receptor IL18R1 encodes a component of the receptor for IL-18. It w…
IL18RAP encodes an accessory protein in the IL-18 receptor complex. The receptor needs coordinated components to translate an extracellular signal into a cellular response. Also called: The accessory component of IL-18 signaling IL18RAP en…
IL1B encodes interleukin-1 beta, a cytokine involved in inflammatory responses and fever. Its production and activation are regulated processes, not simply an on/off consequence of having a common SNP. Also called: IL-1β and the early infl…
IL22 encodes a cytokine that acts on tissues such as epithelial barriers. It can support barrier defense and repair, while its effects depend on the tissue and inflammatory setting. Also called: Barrier defense, repair and excess tissue gr…
IL23A encodes the p19 subunit of interleukin-23. Together with the p40 subunit encoded by IL12B, it forms a cytokine involved in supporting Th17 responses. Also called: The p19 component of IL-23 IL23A encodes the p19 subunit of interleuki…
IL2RA encodes the alpha chain of the interleukin-2 receptor, also called CD25. It is involved in immune activation and regulatory T-cell biology; a soluble receptor measurement is distinct from a DNA result. Also called: CD25 and immune-ce…
IL33 encodes interleukin-33, a signal that can act as an alarmin during tissue stress and promote type 2 immune responses. It belongs in a different functional group from chemokines that recruit cells. Also called: An alarmin in allergic s…
IL5 encodes interleukin-5, a cytokine important to eosinophil growth, survival and activation. Eosinophils are involved in selected allergic and other inflammatory conditions. Also called: An eosinophil-focused cytokine IL5 encodes interle…
IL6R encodes the interleukin-6 receptor. Membrane-bound and soluble receptor pathways help explain why IL-6 biology involves more than the amount of cytokine in a single blood sample. Also called: Receiving and relaying the IL-6 signal IL6…
MTHFS encodes an enzyme that converts 5-formyltetrahydrofolate into 5,10-methenyltetrahydrofolate. This places it in folate interconversion; it is not another name for MTHFR or a direct maker of methylfolate. Also called: Folinic acid has …
RAD50 encodes a DNA-repair protein. The surrounding genomic region also contains regulatory elements relevant to the nearby IL4, IL5 and IL13 cluster, so a locus association can concern more than the coding function of one gene. Also called…
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