Let’s explore “Pulmonary fibrosis: inflammation, repair, and scarring”

Pulmonary fibrosis describes scarring that can impair lung function.

Dr. Purser discusses interleukins and oxidative stress in cystic fibrosis lung disease.

Could Glutathione be the missing link in Cystic Fibrosis Inflammation?

TGFB1 encodes transforming growth factor beta 1, which has roles in immune regulation, tissue repair and extracellular-matrix production. Its effects can include both regulation of inflammation and promotion of fibrosis.

…n to End-Stage Renal Disease (ESRD) IL-8, MCP-1 and kidney inflammation Why this matters See how IL-8 and MCP-1 feature in research on kidney inflammation and scarring. How the pieces connect IL-8 and MCP-1 help recruit immune cells. Res…

Explore transforming growth factor-beta 1, tissue repair, fibrosis, systemic sclerosis, and scarring.

PURSER WELLNESSGlutathione Treatment for Cystic Fibrosis?A conversation with Dr. Purser

…r oral or orally. But what I found, I was looking at cystic fibrosis because when I was a resident at Primary Children's up in Salt Lake City, they used to do these nebulized glutathione treatments. And the guys, the pulmonary were like it …

A subscriber post from Purser Wellness on Substack, covering cytokines and immune signaling, inflammation and antioxidants, gut and digestion.

PURSER WELLNESSThe Hidden Molecule Driving Inflammation: Understanding the Purser Model of HomocysteineFrom the reading room

Most people have never heard of homocysteine , yet this small molecule may hold the key to understanding inflammation, cardiovascular disease, neurological problems, and many chronic conditions. For decades, homocysteine was viewed as a toxic substance in the blood. Doctors were taught that lowering it with B-vitamins might reduce heart disease risk. But research results were inconsistent, leaving many physicians unsure whether homocysteine truly mattered. New research and clinical observations are changing that view. We introduce a new framework called the Purser Model , which explains why ho

Did you know your body’s natural defense against aging and inflammation quietly declines as you get older? Most people don’t realize that glutathione—the “master antioxidant”—drops with age, genetics, and high homocysteine. The result? More

Years ago, I watched cystic fibrosis (CF) patients receive nebulized glutathione that didn’t seem to help. Decades later, our team developed and patented the first fully functional, reduced, and stable form — VARS Glutathione. Why does thi

Explore RAD50, the MRE11–RAD50–NBS1 (MRN) complex, DNA double-strand breaks, genomic stability, and related DNA-repair and antioxidant pathways.