← Genes & pathways

Gene & pathway reference · FROM DR. PURSER’S TEACHING

PEMT

Makes an enzyme involved in producing phosphatidylcholine, a component of cell membranes. Genetic findings alone do not establish a choline deficiency.

Based on teaching by Dan Purser, MD. How we prepare these guides

Updated Sep 23, 2026 · Educational reference
Phospholipid bilayer with hydrophilic heads facing fluid and hydrophobic tails facing inward.
The phospholipid bilayer: a structural connection to the teaching on choline and PEMT.

THE TEACHING CONNECTION

The membrane, liver and bile connection

The membrane, liver and bile connection

PEMT is a central pathway in Dr. Purser’s teaching. It helps the body make phosphatidylcholine, a major membrane phospholipid. His course connects that process with choline demand, liver fat handling, bile, gallbladder history and brain-related questions.

Putting the pieces together

If PEMT is on your report, discuss fat tolerance, reflux, stool changes, gallbladder history, choline and fatty-acid findings, and any past response to phosphatidylcholine. A PEMT variant alone does not diagnose fatty liver or a bile-flow problem.

Where the VARS Triad and MTHFR Daily fit

If you are exploring homocysteine or cytokines, Dr. Purser may discuss MTHFR Daily and the VARS Triad: VARS Glutathione, VARS SOD, and VARS Catalase. He gives glutathione a central place in his approach to antioxidant support.

A gene result alone cannot tell you that you need these products or that they will treat a condition. Review your current results, medicines, goals, and tolerance with your clinician before choosing a product or dose.

A question to bring to your visit

How do my digestive history, current nutrient findings and any clinician-diagnosed liver issues change the importance of this pathway?

Reading your own results

Bring your original report, current results, health history, and medicines to your visit. This information can help you ask questions, but it cannot diagnose a condition or choose a supplement dose for you.

Variant lookup

These names can help you find an entry on your original genetic report. Seeing a name here does not tell you whether it affects your health or whether you need treatment.

Names you may see

Phosphatidylethanolamine N-Methyltransferase · choline · phosphatidylcholine