THE PURSER WELLNESS ENCYCLOPEDIA

Let’s explore “methylation”

Explore this topic as a step-by-step interactive map.MTHFR, the citric acid cycle & ATP
A RELATED COURSEMethylation & B vitamins

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New to this subject? Start with this free introduction.Crash Course on MTHFR & Genetic Terminology

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Health BlogSep 25, 2026

MTHFR C677T Symptoms & The Methylation Paradox: What Your Doctor Missed

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If you’ve been struggling with severe chronic fatigue, unexplained anxiety, or cardiovascular red flags, your genes might be trying to tell you something. Millions of patients walk out of traditional clinics with normal blood tests, only to be told their crippling symptoms are "all in their head." If you carry the C677T variant, you aren't crazy—you are dealing with a breakdown in cellular biochemistry. The Problem With Synthetic Folic Acid The standard advice from standard doctors is to take synthetic folic acid. For someone with the C677T genetic mutation, this is disastrous. Your enzyme pat

FacebookSep 21, 2026

MTHFR gene variants can affect how your body processes folate and methylation, key factors in overall health.

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MTHFR gene variants can affect how your body processes folate and methylation, key factors in overall health. While they don’t directly cause blood sugar crashes, understanding your genetics, nutrition, sleep, stress, and nutrient status c

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FacebookAug 31, 2026

MTHFR gene variants can affect how your body processes folate and methylation, key factors in overall health.

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MTHFR gene variants can affect how your body processes folate and methylation, key factors in overall health. While they don’t directly cause blood sugar crashes, understanding your genetics, nutrition, sleep, stress, and nutrient status

YouTubeAug 6, 2026

OVER-METHYLATION - Are Your B Vitamins Hurting You?

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Can the B vitamins you are taking to support energy and methylation eventually make you feel worse? In this video, Jackson Larkin explains what practitioners often call “overmethylation,” a possible adverse response to supplemental methyl donors such as: • 5-MTHF or methylfolate • Methylcobalamin • Trimethylglycine, also called TMG • Multiple overlapping methylation formulas Possible warning signs can include irritability, anxiety, restlessness, insomnia, brain fog, fatigue, and feeling “wired but tired.” These symptoms do not prove that you are overmethylated. They can have many possible causes. The timing of symptoms, your total supplement exposure, nutrient status, genetics, medications, and health history all need to be considered. In this video, we discuss: • Why methylation is essential • How methyl-donor supplements support the body • Why the right vitamin can become the wrong dose • Ingredients to look for on your supplement labels • Why some people may need lower doses or non-methylated forms • How genetics and intracellular nutrient testing can guide a more personalized plan At Purser Wellness, we believe in a Start Low, Go Slow approach. The goal is not to eliminate methylation. The goal is to provide the right form and amount of support for each individual. Learn more or schedule with Purser Wellness: https://danpursermd.com Educational content only. Do not discontinue prescribed or medically necessary supplements without consulting your qualified healthcare professional. #Overmethylation #MTHFR #Methylation #B12 #Methylfolate #VitaminB12 #TMG #BrainFog #FunctionalMedicine #PurserWellness Follow Dr. Purser! Info: http://www.DanPurserMD.com Supplements: https://www.PhysicianDesigned.com Books: https://www.amazon.com/-/e/B00BIKSGVQ Facebook: https://www.facebook.com/danpursermd Facebook: https://www.facebook.com/PhysicianDesigned Twitter: https://twitter.com/realdanpursermd YouTube: https://www.youtube.com/danpursermd Instagram: https://www.instagram.com/danpurser.md Pinterest: https://www.pinterest.com/danpursermd

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InstagramMar 17, 2026

Struggling to feel better, even with a methylation support supplement? Here’s why it might not be working—and what…

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Struggling to feel better, even with a methylation support supplement? Here’s why it might not be working—and what you can do to finally see results.

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