Let’s explore “transsulfuration”

See how homocysteine connects to cysteine and glutathione. Follow seven simple steps, explore the side routes, and tap a word or building block to learn more.

The folate cycle, methionine cycle, and transsulfuration pathway work together to move methyl groups and process homocysteine.

Chronic inflammatory response syndrome, or CIRS, is a term used in some clinical discussions of persistent symptoms after environmental exposures.

A subscriber post from Purser Wellness on Substack, covering genetics and methylation, inflammation and antioxidants.

A subscriber post from Purser Wellness on Substack, covering genetics and methylation, inflammation and antioxidants.

High homocysteine signals a broken transsulfuration pathway, leaving you unable to detox or convert it into glutathione. This shows up in conditions like PCOS and fibromyalgia, where patients often struggle with inflammation, pain, and even

What I see again and again is an inability to detox caused by failures in the Transsulfuration Pathway. This is your pathway that converts homocysteine to glutathione. If you have MTHFR or 16 other Gene SNPs, you will have problems with thi

What’s transsulfuration? It’s your body’s way of turning inflammatory homocysteine into glutathione, your master antioxidant. 🧬 If your glutathione is low, this pathway (often tied to CBS SNPs) might not be working—and it depends heavily on

If your transsulfuration pathway is off, it’s not just genetics—deficiencies in B6, glutathione, glycine, serine, glutamine, or methionine can block it too. 🧬 Without these, you can’t convert homocysteine to glutathione, leading to inflamma

MTHFR and methylation SNPs are closely related to the methionine and transsulfuration pathways. Everything in your body is connected and trying to balance out. If you are tired, exhausted, or have unending anxiety, there’s a reason your bod

Homocysteine is bad for you, but it’s a critical part of the transsulfuration pathway. You don’t make glutathione wothout it, but when your levels of homocysteine get too high, it becomes majorly problematic for you. Once you have a fix