Let’s explore “Insulin receptor signaling”

Explore interleukin-16, CD4, caspase-3, immune-cell recruitment, and inflammatory signaling.

Explore the p19 and p40 subunits, interleukin-23, and the difference between the IL23A gene and the IL23R receptor.

Explore interleukin-2 receptor alpha, regulatory T cells, soluble IL-2 receptor, and T-cell activation.

Explore epithelial alarmins, the ST2 receptor, ILC2 cells, IL-5, IL-13, and type 2 immunity.

Explore sIL2R, sCD25, soluble interleukin-2 receptor, T-cell activation, and sarcoidosis.

Dr. Purser’s subscriber report on IL-10 dysregulation, immune signaling, and his discussion of the VARS Antioxidant Triad.

Explore rs1801406, BRCA2, DNA repair, cancer-risk interpretation, genetic counseling, and inflammatory signaling; your exact result needs a clinician’s interpretation.

A subscriber post from Purser Wellness on Substack, covering cytokines and immune signaling, hormones.

A subscriber post from Purser Wellness on Substack, covering cytokines and immune signaling.

PURSER WELLNESSMTHFR & The Never-Ending Sugar Crash Cycle: Why You’re Always Tired & Craving SweetsA conversation with Dr. Purser

MTHFR & The Never-Ending Sugar Crash Cycle: Why You’re Always Tired & Craving Sweets If you have an MTHFR variant (C677T or A1298C), you may constantly battle fatigue, sugar cravings, and energy crashes — even when you’re “doing everything right.” In this video, we break down exactly why this happens: How MTHFR/methylation issues impair ATP (energy) production at the cellular level Why your body desperately reaches for quick glucose The vicious cycle of blood sugar spikes → insulin crashes → more cravings & fat storage The downstream effects on antioxidants, DNA repair, and overall energy How to finally break the cycle: Targeted supplementation that fills methylation “holes” (what we learned from 15–20k intracellular tests) Why our MTHFR Daily multivitamin was specifically formulated for this The power of CMA intracellular testing Intermittent fasting (12–16 hrs) Fasted cardio (even just a brisk walk) High-protein, real-food diet with minimal processed sugars If you’re tired of the sugar rollercoaster and want stable energy, this is for you. Links: Read the full Substack article → https://danpursermd.substack.com/p/the-mthfrsugar-craving-cycle Get your CMA intracellular testing & genetics done → Call our office or visit danpursermd.com Shop MTHFR Daily → https://physiciandesigned.com/products/mthfr-daily Have an MTHFR variant? Drop your genotype (heterozygous/homozygous) in the comments — I’m always curious! #MTHFR #SugarCravings #Methylation #ChronicFatigue #Energy #PurserWellness #FunctionalMedicine #IntermittentFasting Follow Dr. Purser! Info: http://www.DanPurserMD.com Supplements: https://www.PhysicianDesigned.com Books: https://www.amazon.com/-/e/B00BIKSGVQ Facebook: https://www.facebook.com/danpursermd Facebook: https://www.facebook.com/PhysicianDesigned Twitter: https://twitter.com/realdanpursermd YouTube: https://www.youtube.com/danpursermd Instagram: https://www.instagram.com/danpurser.md Pinterest: https://www.pinterest.com/danpursermd

Explore Graves’ disease, thyroid eye disease (TED), IL-6, TSH-receptor antibodies, orbital fibroblasts, and treatment research.

A subscriber post from Purser Wellness on Substack, covering cytokines and immune signaling, genetics and methylation.