Let’s explore “MTHFR, homocysteine, and immune signals”

PURSER WELLNESSThe Two Homocysteine Genes to Know #substack #shortsA conversation with Dr. Purser

New public listing. Open the original source for the full discussion.

…er in the VARS Triad. They have different jobs in the body. Homocysteine or immune-signal questions may bring these pathways into your visit, but a pathway connection does not show that you need all three products. How supplementation is ap…

…that helps cells recycle parts. It is studied alongside gut immune function. Your symptoms, family history and actual findings matter more than a gene name alone. Putting the pieces together The teaching links the gut story with IL23R, PEMT…

…biome connection Dr. Purser’s course places FUT2 in its gut–immune map. FUT2 concerns secretor biology and the surface environment of mucosal tissues, helping explain why it appears in discussions of the gut microbiome and nutrient patterns…

…learance and the HRH1/HRH2 receptors that receive histamine signals. Putting the pieces together The reference discusses dietary patterns and clinician-selected antihistamine approaches in this section. These are different mechanisms, not a…

…atically evidence that detoxification is working. How these signals may connect Outlive Your Toxic Genetics links homocysteine, reduced glutathione availability, oxidative signaling and inflammatory messenger release in a proposed feedback …

…es together Dr. Purser discusses this pair when considering immune memory and antibody-response problems. A common regulatory marker is not a proxy diagnosis of CVID or immune amnesia. Pathogenic CD40LG findings can have different, serious …

… stress from a classic cytokine made to communicate between immune cells. A genetic marker cannot establish ongoing tissue injury or diagnose a post-viral syndrome. A question to bring to your visit What evidence supports persistent inflamm…

…d atherosclerosis. The teaching invites readers to consider immune activation alongside the metabolic and vascular picture, rather than interpreting every inflammatory symptom as a direct consequence of IL1B. A question to bring to your vis…

… response. Genetic associations do not identify the correct immune treatment by themselves. A question to bring to your visit Which established clinical findings make the IL-23/IL-17 connection relevant? Variant IDs in the teaching referenc…

…ction of one gene. Putting the pieces together Dr. Purser’s immune panel includes RAD50 through the Th2 locus-control context. Keep that immune-regulatory association distinct from a pathogenic DNA-repair finding. A nearby marker does not p…

Good questions deserve a deeper conversation. Purser Wellness Explore is a new space to follow yours - videos, articles, and guided journeys with me. Start with MTHFR, cytokines, homocysteine, gut health… or whatever thread you’re holding