…actions and reduction reactions, catalyzed by glutathione S-transferase enzymes in cytosol, microsomes, and mitochondria. In the case of N-acetyl-p-benzoquinone imine (NAPQI), the reactive cytochrome P450-reactive metabolite formed by parac…
PSEN1 encodes a presenilin protein that participates in gamma-secretase, a protein-processing complex. Some pathogenic variants can cause familial Alzheimer’s disease; a listed common marker is not equivalent to that diagnosis.
PSEN2 encodes a presenilin protein that participates in gamma-secretase, a protein-processing complex. Some pathogenic variants can cause familial Alzheimer’s disease; a listed common marker is not equivalent to that diagnosis.
GSTO2 encodes glutathione S-transferase omega 2, a redox enzyme with dehydroascorbate reductase activity that connects glutathione chemistry with vitamin C recycling. It is a separate gene from GSTO1.
IFNG encodes interferon gamma, a cytokine involved in cellular immune defense and activation of macrophages. It differs from the Th2 signals more often emphasized in allergic responses.
IL18 encodes interleukin-18, a cytokine that can promote interferon-gamma responses in the appropriate immune context. Its receptor includes components encoded by IL18R1 and IL18RAP.
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…r body uses to make glutathione.
Also called: Cystathionine Gamma-Lyase
From homocysteine toward glutathione
Dr. Purser places CTH in the sulfur-handling pathway that connects homocysteine with glutathione production. In that map, CTH conce…
…hione to process some compounds.
Also called: Glutathione S-Transferase Mu 1
Using glutathione in conjugation
GSTM1 belongs to the glutathione transferase family. These enzymes use glutathione in conjugation reactions involving particular c…
GSTO1 belongs to the omega family of glutathione S-transferases. These enzymes participate in redox chemistry, with roles that differ from the better-known GSTM1 and GSTP1 pathways.
Also called: Glutathione S-Transferase Omega 1
An omega-fa…
…hione to process some compounds.
Also called: Glutathione S-Transferase Pi 1
Using glutathione in conjugation
GSTP1 belongs to the glutathione transferase family. These enzymes use glutathione in conjugation reactions involving particular c…
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