… compounds, including some neurotransmitters. A common variant does not by itself explain mood, attention or stress tolerance.
Also called: Catechol-O-Methyltransferase
Catecholamines and sensitivity
COMT helps process some chemical messeng…
…port, your symptoms and tolerance matter. A common CTH variant does not mean you must avoid sulfur foods or that more building blocks will help.
Where this gene fits in transsulfuration
Dr. Purser places CTH on the route from homocysteine t…
…he folate system, distinct from MTHFR and folate transport into cells.
Also called: Dihydrofolate Reductase
Recycling folate into usable cellular forms
DHFR helps reduce folic acid and dihydrofolate to tetrahydrofolate-related forms used in…
…lps cells respond to estrogen. Receptor signaling is different from the amount of estrogen measured in blood.
Also called: Estrogen Receptor 1
Estrogen signaling depends on the receptor
ESR1 encodes estrogen receptor alpha, which helps cell…
…-5 desaturase step in fatty-acid metabolism. This is why plant-based precursor fats and preformed long-chain omega-3s should not be treated as chemically identical.
Putting the pieces together
If you are reviewing a FADS result, also consid…
…-6 desaturase step in fatty-acid metabolism. This is why plant-based precursor fats and preformed long-chain omega-3s should not be treated as chemically identical.
Putting the pieces together
If you are reviewing a FADS result, also consid…
…down folate from food so it can be absorbed. This is different from the MTHFR step.
Also called: Folate Hydrolase 1
Folate handling begins before remethylation
Dr. Purser’s genetic chapters include FOLH1 in folate handling. The earlier gene…
…r alpha, which helps cells take up folate and has an important role in folate transport at the brain’s barriers. Blood folate and folate availability in the nervous system are not identical measurements.
Also called: Folate Receptor 1
Folat…
…ptake story. The practical teaching is to distinguish nutrient intake, intestinal absorption and cellular transport instead of calling every folate-related result an MTHFR problem. A listed variant does not directly measure folate absorptio…
… in relation to body weight and energy balance. Common variants can contribute to population-level differences in obesity susceptibility, alongside many other genes and environmental factors.
Also called: Fat Mass and Obesity-Associated Gen…
…ap. FUT2 concerns secretor biology and the surface environment of mucosal tissues, helping explain why it appears in discussions of the gut microbiome and nutrient patterns.
Putting the pieces together
The teaching links the gut story with …
…h actual fasting glucose, HbA1c and the person’s clinical context. A G6PC2 finding does not diagnose diabetes or establish a need for those supplements, and glucose-lowering medicines must be considered before adding support.
A question to …
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