… MAO-A, Monoamine Oxidase A
Neurotransmitter breakdown in context
Dr. Purser places MAOA in the neurotransmitter-breakdown part of his brain-chemistry map. The teaching connects it with mood, sleep and medication sensitivity, while warning …
…pamine, and a DNA marker is not a neurotransmitter measurement.
Also called: MAO-B, Monoamine Oxidase B
Breaking down monoamine signals
MAOB encodes monoamine oxidase B, an enzyme involved in breaking down monoamine compounds, including dop…
…lloproteinase 3, an enzyme involved in breaking down components of the extracellular matrix. Controlled remodeling is part of repair, while excess activity can accompany inflammatory tissue damage.
Also called: Matrix Metallopeptidase 3
Rem…
MTHFD1 helps move folate between forms used for different jobs in the body.
Also called: Methylenetetrahydrofolate Dehydrogenase 1
Folate has several working forms
Dr. Purser includes MTHFD1 among genes involved in folate interconversion. T…
…lenetetrahydrofolate Dehydrogenase 1-Like
A mitochondrial contribution to one-carbon metabolism
The homocysteine chapters include MTHFD1L in the wider folate-related genetic map. MTHFD1L concerns mitochondrial one-carbon metabolism; it is d…
… folate used in the processing of homocysteine. Common variants are different from rare variants that cause severe MTHFR deficiency.
Also called: Methylenetetrahydrofolate Reductase, C677T, A1298C, folate, homocysteine
Follow the pathway be…
Makes the methionine synthase enzyme, which uses vitamin B12 in the conversion of homocysteine to methionine.
Also called: Methionine Synthase
The B12-dependent step
In Dr. Purser’s teaching map, MTR is the B12-dependent step that converts …
Helps maintain the activity of methionine synthase, connecting B12-related chemistry with homocysteine metabolism.
Also called: Methionine Synthase Reductase
Keeping the remethylation system working
Dr. Purser teaches MTRR alongside MTR bec…
…ess certain drugs and other compounds. Combinations of variants can influence acetylation status; one SNP usually does not tell the entire story.
Also called: N-Acetyltransferase 2
Acetylation and medication handling
NAT2 encodes N-acetyltr…
NOS3 encodes endothelial nitric oxide synthase, which helps blood vessels generate nitric oxide, a signal involved in vascular relaxation. This pathway is distinct from a blood pressure measurement or a diagnosis of vascular disease.
Also c…
…es NQO1 in the wider redox discussion rather than limiting antioxidant teaching to glutathione. NQO1 participates in quinone reduction, a different enzyme task from superoxide removal by SOD or peroxide handling by catalase.
Putting the pie…
…eceptor genetics and measured cortisol levels answer different questions.
Also called: Nuclear Receptor Subfamily 3 Group C Member 1 / Glucocorticoid Receptor
Receiving the glucocorticoid signal
NR3C1 encodes the glucocorticoid receptor, wh…
Search looks for your words in titles, descriptions, available articles, learning guides, and video captions when available. The closest matches appear first. Duplicate posts are grouped, with links to other places you can read or watch them. Books, chapters, and reports have topic guides here; the original files and full book text are not available in this encyclopedia. Subscriber posts include a title and public summary; open Substack to read the full post.