THE PURSER WELLNESS ENCYCLOPEDIA

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Gene referenceSep 23, 2026

CBS

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…lps move homocysteine into the pathway that supplies building blocks for glutathione. Also called: Cystathionine Beta-Synthase From homocysteine toward glutathione Dr. Purser places CBS in the sulfur-handling pathway that connects homocyste…

Gene referenceSep 23, 2026

CD14

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CD14 helps immune cells recognize microbial components, including bacterial lipopolysaccharide, as part of innate immune signaling. This places it upstream of some cytokine responses. Also called: Cluster of Differentiation 14 How immune ce…

Gene referenceSep 23, 2026

CHDH

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…ed in the homocysteine pathway. Also called: Choline Dehydrogenase Choline can serve more than one purpose CHDH helps convert choline toward betaine, while PEMT helps make phosphatidylcholine. Both involve choline but do different jobs. A n…

Gene referenceSep 23, 2026

COL5A1

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COL5A1 encodes one component of type V collagen, which helps organize collagen fibers. It connects to the strength and structure of tendons, skin and other connective tissues. Also called: Collagen Type V Alpha 1 Chain Collagen structure, t…

Gene referenceSep 23, 2026

COMT

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…an enzyme that helps break down catechol compounds, including some neurotransmitters. A common variant does not by itself explain mood, attention or stress tolerance. Also called: Catechol-O-Methyltransferase Catecholamines and sensitivity …

Gene referenceSep 23, 2026

CTH

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CTH helps make cysteine, one of the building blocks your body uses to make glutathione. Also called: Cystathionine Gamma-Lyase From homocysteine toward glutathione Dr. Purser places CTH in the sulfur-handling pathway that connects homocyste…

Gene referenceSep 23, 2026

DHFR

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…rt into cells. Also called: Dihydrofolate Reductase Recycling folate into usable cellular forms DHFR helps reduce folic acid and dihydrofolate to tetrahydrofolate-related forms used in cellular metabolism. This is one part of the folate sys…

Gene referenceSep 23, 2026

ESR1

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ESR1 encodes estrogen receptor alpha, which helps cells respond to estrogen. Receptor signaling is different from the amount of estrogen measured in blood. Also called: Estrogen Receptor 1 Estrogen signaling depends on the receptor ESR1 enc…

Gene referenceSep 23, 2026

FADS1

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…5D The form of a fatty acid matters Dr. Purser teaches FADS genes as a conversion pathway. FADS1 participates in a delta-5 desaturase step in fatty-acid metabolism. This is why plant-based precursor fats and preformed long-chain omega-3s sh…

Gene referenceSep 23, 2026

FOLH1

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…e MTHFR step. Also called: Folate Hydrolase 1 Folate handling begins before remethylation Dr. Purser’s genetic chapters include FOLH1 in folate handling. The earlier genetics reference explains its role in breaking down polyglutamated food …

Gene referenceSep 23, 2026

FOLR1

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…nsport at the brain’s barriers. Blood folate and folate availability in the nervous system are not identical measurements. Also called: Folate Receptor 1 Folate transport has tissue-specific roles FOLR1 encodes folate receptor alpha, which …

Gene referenceSep 23, 2026

FTO

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FTO is studied in relation to body weight and energy balance. Common variants can contribute to population-level differences in obesity susceptibility, alongside many other genes and environmental factors. Also called: Fat Mass and Obesity-…

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