ADIPOQ encodes adiponectin, a hormone released by fat tissue that participates in insulin sensitivity and fat metabolism. Its name often appears in discussions of triglycerides, body composition and metabolic health.
Also called: Adiponecti…
The genetic-architecture chapter explains that S-adenosylmethionine (SAM) donates methyl groups and becomes S-adenosylhomocysteine (SAH).
Also called: Adenosylhomocysteinase
Methyl-group use leaves another molecule behind
The genetic-archit…
Encodes diamine oxidase, an enzyme involved in breaking down histamine and other amines. DAO is used here as an enzyme nickname; it is also the official symbol of a different gene.
Also called: DAO, Amine Oxidase, Copper Containing 1, Diami…
ATG16L1 is involved in autophagy, a process that helps cells recycle parts.
Also called: Autophagy-Related 16-Like 1
Cellular recycling meets gut immunity
ATG16L1 is involved in autophagy, a process that helps cells recycle parts. It is stu…
BHMT helps recycle homocysteine into methionine using betaine. It is a different route from the folate and B12 pathway.
Also called: BHMT08, Betaine-Homocysteine S-Methyltransferase
Another route through the homocysteine map
BHMT is part of…
BRCA1 helps repair damaged DNA. Clinically classified pathogenic variants can affect inherited cancer risk; a common SNP or a variant of uncertain significance is a different finding.
Also called: Breast Cancer 1
DNA repair and inherited ca…
BRCA2 helps repair damaged DNA. Clinically classified pathogenic variants can affect inherited cancer risk; a common SNP or a variant of uncertain significance is a different finding.
Also called: Breast Cancer 2
DNA repair and inherited ca…
CD14 helps immune cells recognize microbial components, including bacterial lipopolysaccharide, as part of innate immune signaling. This places it upstream of some cytokine responses.
Also called: Cluster of Differentiation 14
How immune ce…
CHDH helps convert choline toward betaine, a nutrient involved in the homocysteine pathway.
Also called: Choline Dehydrogenase
Choline can serve more than one purpose
CHDH helps convert choline toward betaine, while PEMT helps make phosphat…
Makes an enzyme that helps break down catechol compounds, including some neurotransmitters. A common variant does not by itself explain mood, attention or stress tolerance.
Also called: Catechol-O-Methyltransferase
Catecholamines and sensit…
DHFR helps reduce folic acid and dihydrofolate to tetrahydrofolate-related forms used in cellular metabolism. This is one part of the folate system, distinct from MTHFR and folate transport into cells.
Also called: Dihydrofolate Reductase
R…
Encodes an enzyme involved in fatty-acid metabolism.
Also called: Fatty Acid Desaturase 1 / D5D
The form of a fatty acid matters
Dr. Purser teaches FADS genes as a conversion pathway. FADS1 participates in a delta-5 desaturase step in fatty…
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