Let’s explore “HMGB1 & danger signals”

Explore high mobility group box 1, damage-associated molecular patterns (DAMPs), TLR4, RAGE, and cellular stress.

HMGB1 normally has functions inside the cell nucleus. When released outside cells in particular settings, it can act as a damage-associated molecular pattern, or DAMP, participating in inflammatory signaling.

…ells that can release cytokines when they receive stress or danger signals. Follow the pathway Dr. Purser discusses reactive oxygen species, NF-κB, NLRP3, and the cytokines IL-8/CXCL8 and CCL2/MCP-1. His antioxidant teaching pairs glutathi…

Transverse myelitis involves inflammation in the spinal cord and can affect movement, sensation, and bladder function.

Kidney disease has many possible causes.

Dr. Purser’s report looks at the immune signals involved in inflammation of the colon.

Learn how eosinophils and type 2 immune signals are discussed in this teaching.

Follow Dr. Purser’s discussion of folate metabolism and inflammation.

Primary ovarian insufficiency describes reduced ovarian function before age 40.

This immune-mediated condition can affect the optic nerves and spinal cord.

What if fatigue, anxiety, and depression aren't separate problems at all—but warning signals from the same underlying imbalance? For years, we've been told to treat the symptoms. More sleep. More motivation. More medication. But what if th

Could the signals controlling your health be working for you... or against you? Most people have never heard of cytokines, yet these powerful cellular messengers play a critical role in how your body responds to stress, inflammation, recov