Let’s explore “Raynaud’s phenomenon and inflammation”

MTHFD1 helps move folate between forms used for different jobs in the body.

The homocysteine chapters include MTHFD1L in the wider folate-related genetic map.

Makes an enzyme that helps produce a form of folate used in the processing of homocysteine. Common variants are different from rare variants that cause severe MTHFR deficiency.

Helps maintain the activity of methionine synthase, connecting B12-related chemistry with homocysteine metabolism.

NOS3 encodes endothelial nitric oxide synthase, which helps blood vessels generate nitric oxide, a signal involved in vascular relaxation. This pathway is distinct from a blood pressure measurement or a diagnosis of vascular disease.

NQO1 is the gene name for NAD(P)H Quinone Oxidoreductase 1. Learn what a specific result could mean and what to ask about it.

NR3C2 encodes the mineralocorticoid receptor, which responds to hormones such as aldosterone and helps regulate salt and fluid balance. It is distinct from the NR3C1 glucocorticoid receptor.

SHMT1 connects serine and glycine with folate chemistry.

Understand why Dr. Purser teaches glutathione, SOD and catalase as a connected antioxidant team.

CCL4 encodes MIP-1 beta, a chemokine involved in attracting immune cells. It participates in a recruitment network that includes CCL2, CXCL8 and related chemokines.

CD40 encodes a receptor that participates in communication between immune cells, including T-cell help for B-cell responses. Its partner is CD40 ligand, encoded by CD40LG.

CETP transfers cholesteryl esters between lipoprotein particles. This helps explain why the balance of HDL and other lipid particles is more complex than a single cholesterol number.