MTHFD1 helps move folate between forms used for different jobs in the body.
Also called: Methylenetetrahydrofolate Dehydrogenase 1
Folate has several working forms
Dr. Purser includes MTHFD1 among genes involved in folate interconversion. T…
…tetrahydrofolate Dehydrogenase 1-Like
A mitochondrial contribution to one-carbon metabolism
The homocysteine chapters include MTHFD1L in the wider folate-related genetic map. MTHFD1L concerns mitochondrial one-carbon metabolism; it is disti…
…ase, C677T, A1298C, folate, homocysteine
Follow the pathway beyond MTHFR
Dr. Purser teaches MTHFR within a larger folate and homocysteine pathway. MTHFR contributes to production of the folate form used in remethylation; MTR and MTRR connec…
Makes the methionine synthase enzyme, which uses vitamin B12 in the conversion of homocysteine to methionine.
Also called: Methionine Synthase
The B12-dependent step
In Dr. Purser’s teaching map, MTR is the B12-dependent step that converts …
…, which helps process certain drugs and other compounds. Combinations of variants can influence acetylation status; one SNP usually does not tell the entire story.
Also called: N-Acetyltransferase 2
Acetylation and medication handling
NAT2 …
NOS3 encodes endothelial nitric oxide synthase, which helps blood vessels generate nitric oxide, a signal involved in vascular relaxation. This pathway is distinct from a blood pressure measurement or a diagnosis of vascular disease.
Also c…
…1. Learn what a specific result could mean and what to ask about it.
Also called: NAD(P)H Quinone Oxidoreductase 1
Quinone handling within the redox network
Dr. Purser includes NQO1 in the wider redox discussion rather than limiting antioxi…
…answer different questions.
Also called: Nuclear Receptor Subfamily 3 Group C Member 1 / Glucocorticoid Receptor
Receiving the glucocorticoid signal
NR3C1 encodes the glucocorticoid receptor, which helps tissues respond to cortisol and gluc…
…mones such as aldosterone and helps regulate salt and fluid balance. It is distinct from the NR3C1 glucocorticoid receptor.
Also called: Mineralocorticoid Receptor / Nuclear Receptor Subfamily 3 Group C Member 2
Mineralocorticoid signaling …
NTRK2 encodes TrkB, a receptor involved in responding to neurotrophic signals such as BDNF. These signals support nervous-system function and plasticity. NTRK2 is not a phosphatidylserine absorption transporter.
Also called: Neurotrophic Re…
…ed in producing phosphatidylcholine, a component of cell membranes. Genetic findings alone do not establish a choline deficiency.
Also called: Phosphatidylethanolamine N-Methyltransferase, choline, phosphatidylcholine
The membrane, liver an…
PON1 is discussed in relation to how the body handles some compounds and protects certain fats.
Also called: Paraoxonase 1
A different part of antioxidant handling
PON1 appears in Dr. Purser’s redox and conversion teaching alongside GST and…
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