THE PURSER WELLNESS ENCYCLOPEDIA

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Gene referenceSep 23, 2026

ADIPOQ

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ADIPOQ encodes adiponectin, a hormone released by fat tissue that participates in insulin sensitivity and fat metabolism. Its name often appears in discussions of triglycerides, body composition and metabolic health. Also called: Adiponecti…

Gene referenceSep 23, 2026

AOC1

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Encodes diamine oxidase, an enzyme involved in breaking down histamine and other amines. DAO is used here as an enzyme nickname; it is also the official symbol of a different gene. Also called: DAO, Amine Oxidase, Copper Containing 1, Diami…

Gene referenceSep 23, 2026

APOE

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APOE encodes a protein that carries lipids between cells. The familiar APOE e2, e3 and e4 groupings depend on the combination of rs429358 and rs7412, not on either marker read in isolation. Also called: Apolipoprotein E Lipid transport and …

Gene referenceSep 23, 2026

ATG16L1

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ATG16L1 is involved in autophagy, a process that helps cells recycle parts. Also called: Autophagy-Related 16-Like 1 Cellular recycling meets gut immunity ATG16L1 is involved in autophagy, a process that helps cells recycle parts. It is stu…

Gene referenceSep 23, 2026

BHMT

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BHMT helps recycle homocysteine into methionine using betaine. It is a different route from the folate and B12 pathway. Also called: BHMT08, Betaine-Homocysteine S-Methyltransferase Another route through the homocysteine map BHMT is part of…

Gene referenceSep 23, 2026

COL5A1

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COL5A1 encodes one component of type V collagen, which helps organize collagen fibers. It connects to the strength and structure of tendons, skin and other connective tissues. Also called: Collagen Type V Alpha 1 Chain Collagen structure, t…

Gene referenceSep 23, 2026

DAOA

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The older Purser genetics reference uses the heading “DAOA (AOC1)” in its gut section. Also called: D-Amino Acid Oxidase Activator Two similar names, two different pathways You may see DAOA and AOC1 written together in older materials, but …

Gene referenceSep 23, 2026

FOLH1

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FOLH1 helps break down folate from food so it can be absorbed. This is different from the MTHFR step. Also called: Folate Hydrolase 1 Folate handling begins before remethylation Dr. Purser’s genetic chapters include FOLH1 in folate handling…

Gene referenceSep 23, 2026

FOLR2

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FOLR2 encodes folate receptor beta, a folate-binding protein expressed in particular cell types, including subsets of immune cells. It is distinct from the FOLR1 receptor and the SLC19A1 reduced folate carrier. Also called: Folate Receptor …

Gene referenceSep 23, 2026

FUT2

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FUT2 affects substances on the surfaces of the gut and other moist tissues and is studied in relation to the microbiome. Also called: Fucosyltransferase 2 The mucosal and microbiome connection Dr. Purser’s course places FUT2 in its gut–immu…

Gene referenceSep 23, 2026

G6PC2

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G6PC2 encodes a glucose-6-phosphatase-related protein expressed in pancreatic islet cells. Common variation is associated with differences in fasting glucose regulation; it is not the insulin receptor. Also called: Glucose-6-Phosphatase Cat…

Gene referenceSep 23, 2026

GAD1

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GAD1 helps your body make GABA, a chemical messenger, from glutamate. Also called: Glutamate Decarboxylase 1 The glutamate-to-GABA connection Dr. Purser’s course uses GAD/GABA teaching to explain a connection between excitatory and inhibito…

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