…nine Synthase
The B12-dependent step
In Dr. Purser’s teaching map, MTR is the B12-dependent step that converts homocysteine back to methionine. This helps explain why a methylation discussion should include B12 as well as folate, and why ad…
…elps maintain the activity of methionine synthase, connecting B12-related chemistry with homocysteine metabolism.
Also called: Methionine Synthase Reductase
Keeping the remethylation system working
Dr. Purser teaches MTRR alongside MTR beca…
…codes N-acetyltransferase 2, which helps process certain drugs and other compounds. Combinations of variants can influence acetylation status; one SNP usually does not tell the entire story.
Also called: N-Acetyltransferase 2
Acetylation an…
…ndothelial nitric oxide synthase, which helps blood vessels generate nitric oxide, a signal involved in vascular relaxation. This pathway is distinct from a blood pressure measurement or a diagnosis of vascular disease.
Also called: Nitric …
NQO1 is the gene name for NAD(P)H Quinone Oxidoreductase 1. Learn what a specific result could mean and what to ask about it.
Also called: NAD(P)H Quinone Oxidoreductase 1
Quinone handling within the redox network
Dr. Purser includes NQO1 i…
NR3C1 encodes the glucocorticoid receptor, which helps tissues respond to cortisol and glucocorticoid medicines. Receptor genetics and measured cortisol levels answer different questions.
Also called: Nuclear Receptor Subfamily 3 Group C Me…
… which responds to hormones such as aldosterone and helps regulate salt and fluid balance. It is distinct from the NR3C1 glucocorticoid receptor.
Also called: Mineralocorticoid Receptor / Nuclear Receptor Subfamily 3 Group C Member 2
Minera…
NTRK2 encodes TrkB, a receptor involved in responding to neurotrophic signals such as BDNF. These signals support nervous-system function and plasticity. NTRK2 is not a phosphatidylserine absorption transporter.
Also called: Neurotrophic Re…
Makes an enzyme involved in producing phosphatidylcholine, a component of cell membranes. Genetic findings alone do not establish a choline deficiency.
Also called: Phosphatidylethanolamine N-Methyltransferase, choline, phosphatidylcholine
…
…alled: Paraoxonase 1
A different part of antioxidant handling
PON1 appears in Dr. Purser’s redox and conversion teaching alongside GST and NQO1. The genetics reference discusses it in relation to handling particular compounds and protecting…
PSEN1 encodes a presenilin protein that participates in gamma-secretase, a protein-processing complex. Some pathogenic variants can cause familial Alzheimer’s disease; a listed common marker is not equivalent to that diagnosis.
Also called:…
PSEN2 encodes a presenilin protein that participates in gamma-secretase, a protein-processing complex. Some pathogenic variants can cause familial Alzheimer’s disease; a listed common marker is not equivalent to that diagnosis.
Also called:…
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