Let’s explore “Immunoglobulin G — lab reference”

CXCR5 encodes the receptor for CXCL13. This receptor helps guide B cells and certain T cells toward locations where organized immune responses develop. Also called: Following the CXCL13 signal CXCR5 encodes the receptor for CXCL13. This re…

…AH1 encodes an enzyme that breaks down asymmetric dimethylarginine, or ADMA. ADMA inhibits nitric oxide synthase; DDAH1 is part of its clearance system, not the inhibitor itself. Also called: Clearing ADMA helps preserve nitric oxide signa…

F5 encodes coagulation factor V. The well-characterized Factor V Leiden variant, rs6025, can make factor V less responsive to an anticoagulant control mechanism, increasing susceptibility to venous clots. It does not mean the body cannot ma…

F9 encodes coagulation factor IX. Disease-causing variants can result in hemophilia B, an inherited bleeding disorder, but a panel marker is not equivalent to a confirmed disease-causing finding. Also called: Factor IX and the bleeding sid…

GSTO2 encodes glutathione S-transferase omega 2, a redox enzyme with dehydroascorbate reductase activity that connects glutathione chemistry with vitamin C recycling. It is a separate gene from GSTO1. Also called: A distinct member of the …

HMGB1 normally has functions inside the cell nucleus. When released outside cells in particular settings, it can act as a damage-associated molecular pattern, or DAMP, participating in inflammatory signaling. Also called: A cellular protei…

IFNG encodes interferon gamma, a cytokine involved in cellular immune defense and activation of macrophages. It differs from the Th2 signals more often emphasized in allergic responses. Also called: Interferon gamma and macrophage activati…

…onses and help prevent excessive immune-mediated tissue damage. Immune balance includes resolving a response as well as starting one. Also called: The immune system also needs a brake IL10 encodes interleukin-10, a cytokine that can limit …

…ys rather than a stand-alone measure of one cytokine. Putting the pieces together Dr. Purser groups IL12B with pro-inflammatory immune activation. IL-12 is associated with interferon-gamma responses, while IL-23 supports Th17-related respon…

…mune responses, mucus-related processes and tissue remodeling. It overlaps with some IL-4 functions but is not the same signal. Also called: Allergic signaling and tissue responses IL13 encodes interleukin-13, a cytokine involved in Th2 im…

…olved in the survival and activity of immune cells, including natural killer cells and memory CD8 T cells. Its receptor system includes IL15RA. Also called: Supporting immune-cell survival IL15 encodes a cytokine involved in the survival a…

…tor component for IL-15. It helps present IL-15 to responding immune cells, supporting communication that is important for particular lymphocyte populations. Also called: Presenting IL-15 to responding cells IL15RA encodes the alpha recept…