THE PURSER WELLNESS ENCYCLOPEDIA
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What’s searchable?CCL3 encodes MIP-1 alpha, a chemokine involved in attracting and activating immune cells. It is related to CCL4, or MIP-1 beta, but the two genes and proteins are distinct. Also called: MIP-1 alpha and the chemokine cluster CCL3 encodes MI…
CCL4 encodes MIP-1 beta, a chemokine involved in attracting immune cells. It participates in a recruitment network that includes CCL2, CXCL8 and related chemokines. Also called: MIP-1 beta and overlapping recruitment signals CCL4 encodes M…
CCL5, also called RANTES, is a chemokine that helps direct immune-cell movement. Chemokines tell cells where to go, which is different from measuring the total strength of an immune response. Also called: RANTES and immune-cell recruitment…
CD40 encodes a receptor that participates in communication between immune cells, including T-cell help for B-cell responses. Its partner is CD40 ligand, encoded by CD40LG. Also called: A conversation between immune cells CD40 encodes a rec…
…explain why the balance of HDL and other lipid particles is more complex than a single cholesterol number. Also called: Moving cholesterol between lipoproteins CETP transfers cholesteryl esters between lipoprotein particles. This helps exp…
CXCL13 is a chemokine that attracts cells expressing CXCR5, including B cells. This pairing helps organize immune-cell traffic in lymphoid tissues and some chronic inflammatory settings. Also called: Guiding B cells to organized immune sit…
CXCL8 is the gene for IL-8, a chemokine involved in recruiting and activating neutrophils. IL-8 is the protein nickname; CXCL8 is the gene name a DNA report may use. Also called: IL-8: bringing neutrophils to the response CXCL8 is the gene…
…cells and certain T cells toward locations where organized immune responses develop. Also called: Following the CXCL13 signal CXCR5 encodes the receptor for CXCL13. This receptor helps guide B cells and certain T cells toward locations whe…
DDAH1 encodes an enzyme that breaks down asymmetric dimethylarginine, or ADMA. ADMA inhibits nitric oxide synthase; DDAH1 is part of its clearance system, not the inhibitor itself. Also called: Clearing ADMA helps preserve nitric oxide sig…
…The well-characterized Factor V Leiden variant, rs6025, can make factor V less responsive to an anticoagulant control mechanism, increasing susceptibility to venous clots. It does not mean the body cannot make factor V. Also called: Factor…
…ulation factor IX. Disease-causing variants can result in hemophilia B, an inherited bleeding disorder, but a panel marker is not equivalent to a confirmed disease-causing finding. Also called: Factor IX and the bleeding side of coagulatio…
GSTO2 encodes glutathione S-transferase omega 2, a redox enzyme with dehydroascorbate reductase activity that connects glutathione chemistry with vitamin C recycling. It is a separate gene from GSTO1. Also called: A distinct member of the …
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