Makes the methionine synthase enzyme, which uses vitamin B12 in the conversion of homocysteine to methionine.
Also called: Methionine Synthase
The B12-dependent step
In Dr. Purser’s teaching map, MTR is the B12-dependent step that converts …
…s maintain the activity of methionine synthase, connecting B12-related chemistry with homocysteine metabolism.
Also called: Methionine Synthase Reductase
Keeping the remethylation system working
Dr. Purser teaches MTRR alongside MTR because…
NAT2 encodes N-acetyltransferase 2, which helps process certain drugs and other compounds. Combinations of variants can influence acetylation status; one SNP usually does not tell the entire story.
Also called: N-Acetyltransferase 2
Acetyla…
NOS3 encodes endothelial nitric oxide synthase, which helps blood vessels generate nitric oxide, a signal involved in vascular relaxation. This pathway is distinct from a blood pressure measurement or a diagnosis of vascular disease.
Also c…
NR3C2 encodes the mineralocorticoid receptor, which responds to hormones such as aldosterone and helps regulate salt and fluid balance. It is distinct from the NR3C1 glucocorticoid receptor.
Also called: Mineralocorticoid Receptor / Nuclear…
NTRK2 encodes TrkB, a receptor involved in responding to neurotrophic signals such as BDNF. These signals support nervous-system function and plasticity. NTRK2 is not a phosphatidylserine absorption transporter.
Also called: Neurotrophic Re…
Makes an enzyme involved in producing phosphatidylcholine, a component of cell membranes. Genetic findings alone do not establish a choline deficiency.
Also called: Phosphatidylethanolamine N-Methyltransferase, choline, phosphatidylcholine
…
PSEN2 encodes a presenilin protein that participates in gamma-secretase, a protein-processing complex. Some pathogenic variants can cause familial Alzheimer’s disease; a listed common marker is not equivalent to that diagnosis.
Also called:…
PTGS2, commonly called COX-2, encodes an enzyme involved in prostaglandin production. Prostaglandins participate in pain, fever and inflammatory signaling.
Also called: COX2, Cyclooxygenase 2
COX-2 and inflammatory prostaglandins
PTGS2, com…
SOD2 works in mitochondria as part of the body’s antioxidant defenses.
Also called: Superoxide Dismutase 2
Superoxide defense in its own setting
Dr. Purser teaches SOD as one member of an antioxidant team. SOD2 works in mitochondria and use…
SOD3 works outside cells as part of the body’s antioxidant defenses.
Also called: Superoxide Dismutase 3
Superoxide defense in its own setting
Dr. Purser teaches SOD as one member of an antioxidant team. SOD3 works outside cells and uses co…
TCN2 helps carry vitamin B12 in the body. A gene result alone cannot tell you your B12 status.
Also called: Transcobalamin II
B12 must be carried as well as consumed
TCN2 appears in Dr. Purser’s homocysteine and methylation map because it c…
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