All resources: page 25

IL-6 is a messenger; IL-6R is the receptor that receives it.

A subscriber post from Purser Wellness on Substack, covering cytokines and immune signaling, genetics and methylation.

A subscriber post from Purser Wellness on Substack, covering cytokines and immune signaling, genetics and methylation.

Explore interleukin-8, neutrophils, CXCR1, CXCR2, and immune-cell recruitment.

See how IL-8 and MCP-1 feature in research on kidney inflammation and scarring.

IL10 encodes interleukin-10, a cytokine that can limit inflammatory responses and help prevent excessive immune-mediated tissue damage. Immune balance includes resolving a response

IL12B encodes the p40 subunit shared by IL-12 and IL-23. This makes it an intersection between immune pathways rather than a stand-alone measure of one cytokine.

Explore the p40 subunit, IL-12, IL-23, and Th1 and Th17 pathways.

IL13 encodes interleukin-13, a cytokine involved in Th2 immune responses, mucus-related processes and tissue remodeling. It overlaps with some IL-4 functions but is not the same si

IL15 encodes a cytokine involved in the survival and activity of immune cells, including natural killer cells and memory CD8 T cells. Its receptor system includes IL15RA.

IL15RA encodes the alpha receptor component for IL-15. It helps present IL-15 to responding immune cells, supporting communication that is important for particular lymphocyte popul

Explore interleukin-15 receptor subunit alpha, IL-15 signaling, natural killer cells, CD8+ T cells, and pain.

IL16 encodes interleukin-16, a cytokine involved in attracting and influencing immune cells, including CD4-expressing cells. Its recruitment role helps separate it from other numbe

IL17A encodes interleukin-17A, a cytokine involved in defense at tissue barriers and inflammatory signaling. It belongs to the Th17 pathway, which is supported by signals including

IL18 encodes interleukin-18, a cytokine that can promote interferon-gamma responses in the appropriate immune context. Its receptor includes components encoded by IL18R1 and IL18RA

IL18R1 encodes a component of the receptor for IL-18. It works with an accessory component, IL18RAP, to support IL-18 signaling.

IL18RAP encodes an accessory protein in the IL-18 receptor complex. The receptor needs coordinated components to translate an extracellular signal into a cellular response.

Explore interleukin-18 receptor accessory protein, IL18R1, MyD88, and mucosal and systemic inflammation.

IL1B encodes interleukin-1 beta, a cytokine involved in inflammatory responses and fever. Its production and activation are regulated processes, not simply an on/off consequence of

Explore interleukin-1 receptor antagonist (IL-1Ra), rs1794066, and regulation within the IL-1 pathway.

IL21 encodes a cytokine involved in regulating lymphocytes, including B-cell responses. It sits within an immune network that connects T-cell help, antibody responses and inflammat

IL22 encodes a cytokine that acts on tissues such as epithelial barriers. It can support barrier defense and repair, while its effects depend on the tissue and inflammatory setting

IL23A encodes the p19 subunit of interleukin-23. Together with the p40 subunit encoded by IL12B, it forms a cytokine involved in supporting Th17 responses.

Explore the p19 and p40 subunits, interleukin-23, and the difference between the IL23A gene and the IL23R receptor.

IL23R encodes part of the receptor that receives IL-23 signals. This connects the gene to the maintenance of Th17-related immune responses, which differ from the Th2 patterns discu

IL2RA encodes the alpha chain of the interleukin-2 receptor, also called CD25. It is involved in immune activation and regulatory T-cell biology; a soluble receptor measurement is

Explore interleukin-2 receptor alpha, regulatory T cells, soluble IL-2 receptor, and T-cell activation.

IL33 encodes interleukin-33, a signal that can act as an alarmin during tissue stress and promote type 2 immune responses. It belongs in a different functional group from chemokine

IL4 encodes interleukin-4, a cytokine involved in Th2 immune responses and antibody class switching, including pathways related to IgE. It operates alongside IL-5 and IL-13 rather

IL5 encodes interleukin-5, a cytokine important to eosinophil growth, survival and activation. Eosinophils are involved in selected allergic and other inflammatory conditions.

Dr. Purser’s subscriber report on IL-5, cytokine genetics, and the topics discussed in his homozygous IL5 variant report.

IL6 encodes interleukin-6, a cytokine involved in immune responses and acute-phase signaling. It can appear in discussions of infection, chronic inflammation and metabolic health,

By Dan Purser MD Pathway-level clinical interpretation focused on inflammatory interaction, likely signs, and likely complications

IL6R encodes the interleukin-6 receptor. Membrane-bound and soluble receptor pathways help explain why IL-6 biology involves more than the amount of cytokine in a single blood samp

IMAGINE A TOPICAL PAIN GEL THAT REALLY REALLY WORKS. PAIN WHERE YOU APPLY IT IS JUST GONE. LIKE MAGIC. THAT ACHING ELBOW? FULL RANGE OF MOTION WITH NO PAIN. THAT BAD KNEE? TWO HRS

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Imagine living with pain so intense that a broken finger or injured toes could be mistaken for "just another bad day." For many people with fibromyalgia, that's a frightening reali

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Imagine waking up each morning with a renewed zest for life, feeling energized and ready to take on the world. By mastering your methylation and addressing underlying intracellular

Age and assay-specific. Important when interpreting IgA-based celiac testing.

Age and assay-specific. Ask your clinician to consider subclasses or electrophoresis when indicated.

Age and assay-specific.

A post from Purser Wellness on Substack, covering cytokines and immune signaling, inflammation and antioxidants.

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4 Tips to Support Good Brain Health

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In case you were wondering, I look at vitamin deficiencies, specifically caused by genetic errors. This is ROOT CAUSE medicine. If you have any questions about testing or becoming

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In my video this week I discusses several situations when genetics may be the root cause of anxiety and depression. Discover which genetic testing and supplements can help you addr

In October of 2019 I was asked to prepare a talk and SLIDE SHOW FOR THE AMERICA ACADEMY OF ANTI-AGING MEDICINE for June of 2020 in Orlando; I finally gave that talk last month in M

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In this week's video I discuss a Meta - Analysis where I draw correlations between Crohn's disease, Ulcerative Colitis, other inflammatory bowel diseases and B12 / folate deficienc