MTHFS
Some search terms matched…se forms. Discuss the actual product and response alongside B12 and homocysteine findings rather than assigning a folate form solely from rs6495446.
A question to bring to your visit
How does my current folate form enter the pathway, and wh…
RAD50
Some search terms matched…egion also contains regulatory elements relevant to the nearby IL4, IL5 and IL13 cluster, so a locus association can concern more than the coding function of one gene.
Also called:
DNA repair and a nearby Th2 regulatory region
RAD50 encode…
TGFB1
Some search terms matchedTGFB1 encodes transforming growth factor beta 1, which has roles in immune regulation, tissue repair and extracellular-matrix production. Its effects can include both regulation of inflammation and promotion of fibrosis.
Also called:
Repai…
TNFRSF10A
Some search terms matched…e in regulated cell-death pathways. TRAIL itself is encoded by TNFSF10.
Also called:
DR4 receives the TRAIL signal
TNFRSF10A encodes death receptor 4, or DR4, a receptor that can receive the TRAIL signal and participate in regulated cell-d…
TNFSF10
Some search terms matched…ll death through particular receptors. It is a different member of the TNF-related signaling family from TNF itself.
Also called:
TRAIL and regulated cell death
TNFSF10 encodes TRAIL, a signaling protein involved in regulated cell death th…
Transsulfuration: from homocysteine to glutathione
Some search terms matched…en simple steps, explore the side routes, and tap a word or building block to learn more.
Also called: Transsulfuration, Transsulphuration, Sulfur pathway, Cysteine synthesis, Glutathione synthesis, CBS pathway, CTH pathway
Two directions f…
CCL2 / MCP-1
Some search terms matched… recruit monocytes through the CCR2 receptor. Monocytes can become macrophages, cells that remove debris and participate in inflammation.
Follow the pathway
Dr. Purser follows the CCL2–CCR2 pathway through blood-vessel, kidney, and metabol…
CD14 & endotoxin signaling
Some search terms matchedExplore membrane and soluble CD14, lipopolysaccharide (LPS), TLR4, and innate immune activation.
Understand the connection
CD14 helps the immune system recognize lipopolysaccharide, or LPS, from the outer surface of certain bacteria. It ap…
CD40 & immune-cell communication
Some search terms matchedExplore CD40L, antigen-presenting cells, antibody class switching, and autoimmunity.
Understand the connection
CD40 is a receptor involved in communication between immune cells. Its partner, CD40L, helps activated T cells communicate with …
IL18RAP co-receptor
Some search terms matched…AP is an accessory part of the IL-18 receptor. IL18R1 helps bind the cytokine; IL18RAP helps the receptor complex send its signal inside the cell.
Follow the pathway
Dr. Purser follows this receptor complex through MyD88 and NF-κB signalin…
IL-21
Some search terms matched…h17 cells, IL-21R, JAK/STAT terminology, and cellular redox balance.
Understand the connection
IL-21 is produced by immune cells including follicular helper T cells and Th17 cells. It influences B cells, antibody responses, and other parts…
TLR2
Some search terms matchedExplore Toll-like receptor 2, microbial and damage signals, TLR1, TLR6, and MyD88 signaling.
Understand the connection
TLR2 is a pattern-recognition receptor that helps immune cells detect components of microbes and damaged tissue. It ofte…
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